Research and Development
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Study: Small Group of Genes in Lung Fibroblasts May Help Promote IPF
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Study: Small Group of Genes in Lung Fibroblasts May Help Promote IPF
Researchers identified a small group of genes that may promote idiopathic pulmonary fibrosis (IPF) after analyzing gene expression profiles in fibroblasts isolated from the lungs of patients with the disease.
The study, “Global Gene Expression Analysis in an in vitro Fibroblast Model of Idiopathic Pulmonary Fibrosis Reveals Potential Role for CXCL14/CXCR4,” was published in the journal Scientific Reports.
“Our findings, present a possible therapeutic target for IPF and a model for the study and discovery of novel protein and processes in this terrible disease,” the research team said.
According to the researchers, fibroblasts are “the central effector cell of progressive fibrosis.” To gain a better understanding of these cells, they analyzed gene expression of pulmonary fibroblasts directly after isolating them from IPF patients and again after three weeks of culturing the cells in a lab, or in vitro culture. The team also analyzed gene activity in fibroblasts from nondisease donors.
Read more about this study here: “Small Group of Genes in Lung Fibroblasts May Help Promote IPF, Study Suggests“
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