CrystecPharma signed a letter of understanding with Iconovo to develop innovative dry powder inhaler solutions for the treatment of patients with lung diseases, including pulmonary fibrosis. Direct delivery of medications into the lungs permits their rapid uptake via a non-invasive route. The two key factors that determine successful…
The demographic and clinical characteristics of patients with idiopathic pulmonary fibrosis (IPF) in Spain are similar to those of IPF patients in other countries, allowing for comparison with other registries and cohorts, a study has found. The study, “Demographic and Clinical Profile of Idiopathic Pulmonary Fibrosis Patients in…
Gli proteins can trigger fibroblast activation and support their role in promoting fibrosis in the lungs in response to damage to the airspaces, a study in mice shows. The study, “Gli signaling pathway modulates fibroblast activation and facilitates scar formation in pulmonary fibrosis,” was published in the journal…
Lung Therapeutics announced that it has raised $36 million in Series C financing to fund two projects, including a healthy volunteer Phase 1 clinical trial testing LTI-03, an experimental therapy for idiopathic pulmonary fibrosis (IPF). Currently approved therapies for IPF can slow disease progression, but cannot restore…
Measuring three specific biomarkers — nitric oxide, PGE2, and 8‐isoprostane — in the exhaled breath condensates (EBC) or bronchoalveolar lavage fluids (BALF) of patients with different forms of interstitial lung disease or other lung diseases does not show diagnostic potential, a study suggests. The study, “Exhalative Breath Markers Do…
A long-term collaboration was announced to accelerate the discovery of new medicines for idiopathic pulmonary fibrosis (IPF) and chronic kidney disease (CKD) by combining BenevolentAI’s expertise in artificial intelligence (AI) and machine learning with AstraZeneca’s pharmaceutical and clinical data. BenevolentAI, a U.K.-based company, developed an AI system…
Algernon Pharmaceuticals announced its plans to conduct a new in vivo animal study comparing its lead anti-fibrotic NP-251 compound with clinically relevant doses of both Esbriet (pirfenidone) and Ofev (nintedanib), two approved medicines for the treatment of idiopathic pulmonary fibrosis (IPF). IPF is a chronic lung disease characterized by a progressive and irreversible decline in…
The incidence of lung cancer is greater among patients with idiopathic pulmonary fibrosis (IPF), compared with the general population, and is associated with a worse prognosis, a new U.S. study reports. The study, “Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease –…
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