An international clinical trial testing LTI-03, Rein Therapeutics’ inhaled treatment candidate for idiopathic pulmonary fibrosis (IPF), is now recruiting participants at sites in five countries. The Phase 2 trial, dubbed RENEW (NCT06968845), aims to enroll approximately 120 people with IPF, ages 40 and older. Eligible participants will…
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The oral therapy Jascayd (nerandomilast) has been approved in the European Union for adults with idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF). The marketing authorization from the European Commission follows a positive recommendation from a regulatory committee and marks the first new IPF therapy approved…
The Pulmonary Fibrosis Foundation (PFF), an advocacy group dedicated to advancing care for people with pulmonary fibrosis, has added two new members to its board of directors. Both new board members are physicians with extensive experience caring for people with pulmonary fibrosis, which causes scarring in the lungs,…
Celea Therapeutics received $180 million in financing to develop deupirfenidone (LYT-100), an investigational therapy that the company says has the potential to serve as a new standard of care for people with idiopathic pulmonary fibrosis (IPF). The funding will support the planned launch of SURPASS-IPF (NCT07284602), a…
Problems in a cell death process called ferroptosis may contribute to the formation of scar tissue in the lungs in idiopathic pulmonary fibrosis (IPF), a study suggests. In ferroptosis, which is an iron-dependent process, reactive oxygen molecules damage cell membranes, leading to cell death. In the study, the researchers described…
GRI Bio‘s experimental oral therapy GRI-0621 (tazarotene) has received orphan drug designation from the U.S. Food and Drug Administration (FDA) for the treatment of idiopathic pulmonary fibrosis (IPF), a disease with no known cause that’s marked by inflammation and fibrosis, or scarring, that damages the lungs. The developer…
Familial pulmonary fibrosis (FPF) makes up a notable portion of all cases of interstitial lung disease, disorders marked by scarring in the lungs, and tends to appear differently from non-familial versions of the disease, a large, multicenter study has found. While survival outcomes were similar between the two groups,…
Vaccines based on protein fragments unique to the scar-forming cells that drive idiopathic pulmonary fibrosis (IPF) significantly reduced lung scarring in both mouse models and human cell experiments, according to a study. While the vaccine approach showed promise in mice, advancing it to clinical trials will require patient selection…
A regulatory committee of the European Medicines Agency is urging approval of the oral therapy Jascayd (nerandomilast) in the European Union for treating adults with idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF), two forms of the respiratory disease. While the European Commission — which makes all final…
Two Phase 3 clinical trials testing Tyvaso (treprostinil) in people with idiopathic pulmonary fibrosis (IPF) both met their main goals, showing that the inhalation therapy significantly outperformed a placebo at slowing the decline in lung function among IPF patients. With these data in hand, Tyvaso’s developer, United…
