The Envisia Genomic Classifier test for idiopathic pulmonary fibrosis (IPF) diagnosis received a draft Medicare local coverage determination (LCD) through the MolDx (Molecular Diagnostics) service program, according to Veracyte. The decision is a key step in making the test widely available to patients, the company says.
A new in vitro lung tissue-on-a-chip system mimics tissue stiffening in pulmonary fibrosis (PF), and offers an accurate and rapid way to test treatment candidates, according to a new study. The study, “Fibrotic microtissue array to predict anti-fibrosis drug efficacy,” was published in the journal Nature…
The idiopathic pulmonary fibrosis (IPF) treatment candidate BBT-877 eased lung fibrosis (scarring) in a mouse model, according to South Korea-based Bridge Biotherapeutics. The company believes that BBT-877 may become the “best-in-class” medication for IPF. Data from a preclinical study on BBT-877 was presented at the 2nd Annual IPF…
Laparoscopic surgery in idiopathic pulmonary fibrosis (IPF) patients with acid reflux is safe and well-tolerated, but does not appear to significantly ease the decline in respiratory function that’s thought to be aggravated by reflux, according to a Phase 2 study. The research, “Laparoscopic anti-reflux surgery for…
An immune pathway that includes a molecule known as IL-33 and its receptor, ST2, may be key in the development and progression of pulmonary fibrosis (PF), according to new research in mice. The study, “The IL-33 Receptor ST2 Regulates Pulmonary Inflammation and Fibrosis to Bleomycin,” was published…
Targeting a key protein of the innate immune system called TLR4 could be a new way of treating people with pulmonary fibrosis (PF) and other fibrotic disorders, according to a Northwestern University study. The study, “TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung,” was published…
Pulmonary fibrosis (PF) and other lung diseases may be late complications in patients with Type 2 diabetes, according to a German study. The study, “Breathlessness and Restrictive Lung Disease: An Important Diabetes-Related Feature in Patients with Type 2 Diabetes,” was published in the journal Respiration. Breathlessness…
NuMedii will collaborate with researchers at Yale School of Medicine and Brigham and Women’s Hospital to develop precision therapies and biomarkers for idiopathic pulmonary fibrosis (IPF). Under this strategic research collaboration, the company will work with teams of two leading experts in interstitial lung disease: Naftali Kaminski, MD, a…
The introduction of bias in the design and analysis of studies likely explains a reported reduction of mortality with antacid therapy in patients with idiopathic pulmonary fibrosis (IPF), according to a new Canadian review study. The research, “The effect of anti-acid therapy on survival in idiopathic…
A common oral medication for type 2 diabetes called metformin was seen to quickly reverse pulmonary fibrosis in a mouse model of the disease and lessen fibrosis in lung tissue of PF patients, a study reports, adding that similar compounds might have similar benefits. The research, “Metformin reverses…
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