Hi.. I am also on O2 24/7 after a recent hospitalization for pneumonia and hate my running faucet nose. So far, I have been unsuccessful with sprays as they give me nosebleeds as well. I do take a child’s dose of NyQuil at night and the Benadryl in it shuts down the faucet and helps me sleep. It usually lasts much of the next day as well. The Dr added moisture to my concentrator and is hoping that will help with the dryness. I am considering the child dose of Claritin (or something like that) for breakthrough hours.