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  • I began taking Ofev immediately after I was diagnosed, and stayed on it for almost 3 years.  I had G I issues starting about 6 months after I began taking it.  They progressed until I virtually lost my ability to tolerate it and became malnourished.  I am now on Esbriet with no visible side effects, however I have now been diagnosed with stage 3 chronic kidney disease.  I have no idea if either drip would be the cause of that.  I do have high blood pressure and believe that may be a factor.  I believe studies have proven both drugs are effective in slowing the progression.