I stared OFEV in September 2016. I began t experience side effects around Christmas of that year. Mostly severe lower bowl discomfort at night, some diarrhea, but not problematic. I put up with this discomfort for 15 months. At that time after consulting with the OFEV nurse my dosage was reduced to 100 mg. per day. Since going on the 100 mg doses I no longer experience lower bowl discomfort, and am able to sleep through the night. When I went on the 100mg dosage I also started taking metamucil twice a day which has normalised my bowl function.