Enzyme Can Start Process That Leads to Tissue Scarring Being Reversed, Study Shows
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An enzyme can start a chain of events that leads to cells involved in tissue scarring reversing their fibrosis-generating activity, British and American researchers have discovered.
The study dealt with the enzyme’s effect on myofibroblasts — cells involved in wound healing and inflammatory response. The discovery could lead to new therapies for the lung scarring disease pulmonary fibrosis and other fibrotic disorders, researchers said.
The study, “Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to determine profibrotic or antifibrotic cell phenotype,” appeared in the journal Science Signaling.
Fibrosis is the excessive growth, hardening, or scarring of connective tissue due to inflammation. It can cause permanent organ damage and chronic diseases such as pulmonary and cardiac fibrosis, asthma, atherosclerosis, cirrhosis, and scleroderma.
Researchers from Wales and the U.S. wanted to know more about the cell surface protein CD44’s role in fibrosis. Scientists have linked faulty versions of the protein not only to fibrosis disorders, but also to cancer, blood vessel diseases, wound healing problems, and immune system dysfunction.
CD44 plays a number of roles in the body. One way it does this is through alternative splicing, or creating different molecules of messenger RNA from the same gene when protein is produced.
Scientists say CD44 is a receptor for a molecule called hyaluronan. The British and American researchers discovered that hyaluronidase 2, an enzyme that breaks down hyaluronan, regulates CD44 gene splicing in myofibroblasts’ nucleus. The leads to a variation of CD44 called CD44v7/8.
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While CD44 prompts fibrosis-promoting myofibroblasts to differentiate, or develop into specialized versions of themselves, CD44v7/8 prevents and reverses their differentiation.
This was a surprising finding because scientists had previously thought that hyaluronidase 2 was involved only in the breakdown of sugar chains. “We were amazed to discover that the protein [hyaluronidase 2] can bind to RNA in a cell and alter its activity,” Soma Meran, the study’s senior author, said in a press release.
“In the case of the cells responsible for fibrosis and scar formation, we can potentially use this technique to stop them from producing scar tissue,” Meran said. “This opens up exciting new research avenues in the study of fibrosis.”
The team is particularly interested in finding ways to prevent and reverse chronic kidney disease. The disorder, which is difficult to treat, accounts for around 3 percent of Britain’s National Health Service budget. Many patients require dialysis or kidney transplants, which carry a high risk of complication.
Now the scientists plan to study hyaluronidase 2’s structure for clues to how it influences protein production. The ultimate goal is to develop therapies with synthetic proteins that mimic the enzyme’s beneficial effects.
Thomas Johnson
How Cano e get in a study?
antonietta moore
please mail some information, I WUOLD LIKE TO PARTICIPATE, I HAVE LUNG FIBROSIS.
LAWRENCE
Please could I have more info on this product, I would love to be part of the trials I have I P F.
Dennis Van Weelden
would like to be a candidate for this I have D.I.P.
which is a type IPF.
Thomas Johnson
How can someone get in this study?
Patricia Alexander
I have been diagnose with Pulmonary Fibrosis who can I be part of the study?
Patricia Alexander.
[email protected]
I live in the suburbs of Chicago in the city of Wheaton. Illinois
Larry Schexnaydre
when trials begin for testing in IPF!!!!!!?
Sharon Borneman
Can I get on study I have ipf
stan clark
Hi I have pulmonary fibrosis and would like to know more about this possible reversal method but how come no one is replying to all the comments.
Timothy Middleton
Can I please get into this study? Will sign all the waivers needed.
Colleen walker
How can I get in this study. How can I get on the board
Charlotte Kleinpeter
I would like information on test studies available for IPF
Dania Parisé
comment faire partie de cette étude
Chuck T
Absolutely I would desire to know more about this enzyme.
I Have sarcoidosis of the lungs and get winded very easily.
I have been taking serrapeptase for several years as I believed it to help break down scar tissue. But upon viewing my last chest x Ray, my MD said concerning the serrapeptase “ I believe you have received wrong information. Yes I would try this new enzyme.
Secrets
Try a combination of tretnal and vitamin e it works better than sereapeptase
E Matthews
What Is a good dosage of Tretnal &
Vitamin E ? I'm 176 lb & 83 yrs old.
Brian Bayliss
How can my husband get more information about this trial please.
[email protected]
He has end stage IPF
Brian Bayliss
Husband should have read "I"
Chris Heller
Would this be able to help interstitial lung decease? I hope you can answer this for me
Joseph Hamilton
Can my father participate in this study? Any study?? He has IPF. Who can point us in the right direction???
[email protected]
801-463-7806
Frances Rowe
I have been diagnosed with IPF. Please would like to be considered for the study. Frances Rowe
Charles Riggs
I too need to be included in the fibrosis study please
Jorge Delgado
Would love to know more about this study and potential treatment. How do I get more information?
Jeanette Brooks
I am also interested in this study
Diane Thompson
I have pulmonary fibrosis and would like to be involved in the study.
Hyun Chung
I would like to get more information about this study?
Shirley Estep
I would like to be a part of this study
r.r. rathi
i shall also to know in detail, one of my close relative has ipf, age 62. pls inform [email protected]
Bill May
I have ideopathic pulmonary fibrosis.
Will serrapeptase reverse that?
Serena
Hello,
I have been diagnosed with sarcoidosis of lungs and would like more information about this study and possibility of participating in it.
Thanks.
[email protected]
Marion
Can Serrapeptase help with IPF?
Mary Tiller
I have interstitial fibrosis! I was diagnosed in 2009! I am on oxygen and lung function is in the 40's. Please let me know if this might help me.
Tyrone Sannicolas
I have inerstical lung disease and hardening of the lungs I am on a 20 liter flow at rest of oxygen. Any movement and my saturation just plummets. Can you please help me.
Peggy kettunen
Very interested in this study. Currently on serracor and serrapeptase enzymes since Jan of 2016. How do i find out more info?
May Mya Win
This would certainly be a breakthrough. It could reverse the scarring, reduce lung stiffness and increase vital capacity.
Available medications only halt fibrosis reduce progression somewhat.
But what are the adverse effects?
It is so interesting and I would like to know more.
Patricia Vincent
Am in the process of being tested for lung fibrosis. I would be interested in any information or study that can help me
Anna
My dad has pf due to scleroderma. We're willing to do anything, please let us know about any trials.
Liaq
I would like to know more regrading the success of this research , as my mother has this illness and i hope she can avoid lung transplant.
Christina
Why are there no replies to people's pleas to be apart of this study? Ridiculous.
Jeffrey McDaniel
Recent dx of IPF. No symptoms other than a high res CT scan. Please email me if opportunity for study is available.
[email protected]
Shayne
Please email me if you can includeme in a study for pulmonary fibrosis. I am on oxygen. Only 42 years old.
Regards
Shayne
[email protected]
Victoria Price
Count me in plz! 48 and on full time Oxygen therapy. 5 liters.
Please call myself or my power of attorney. I have gotten into A-mazing shape. Mind, body and spirit. I have sought counseling and pulmonary rehab. My goal is to be 100% eligible for a lung transplant. I would much rather do clinical trials.
Sincerely,
Victoria Price
[email protected]
4424004617
Sandra Hall, POA
[email protected]
9092774025
Judy Wagner
Please enroll my husband in a trial. He was diagnosed with IPF in June 2018. We live in Helena MT. We are willing to travel. Presently he is on ofev. This drug has rough side effects. For now it would be desirable for him to stay on ofev while doing a trial. He is on O2 3L. We are very frustrated that no trials have been available for us. Thanks!
Ashish Sharma
How can I participate in this trial, pls advise
Carolyn Chamberlain
Would love to participate before it's too late.
azmee
My wife suffer from lung fibrosis. This moment she is taking curcumin from life extentions. Is there any type of enzyme good for lung scars.
Tuan Martin
I'm on it right now and it has stable the scaring in my lungs but having reversed any scaring and I've been on it for almost a year. Just be careful of the side affects.
I'm still here and hoping some of the scaring goes away soon. But at least my scaring hasn't gotten worse.
Phil
There are so many studies going on and none are available for us to try.
If you are famous , you'll get preferential treatment.
The rest of us ordinary people not eligeble.
And if there is a cure coming,it will be too late for most of us.
Richard Jarvis
How can I participate in these trials? I have ILD and live in the Boston area.
Gwe rienti
How can I get in the study? I have of for 11 yrs now & getting worse since I broke my hip & pelvis.
Lizzy
Pls how can l get in the study
bfree
Who would pay for such a study? They want to develop "synthetic proteins that mimic the enzyme’s beneficial effects." Read "drugs." They don't want to give you what works. Hyaluronidase 2 is natural and can't be pattented to make big money on it. Big Pharma wants to make an expensive drug! Don't you hate modern medicine? They are only interested in your money! To bad you can't buy hyaluronidase 2 from the corner supplement store! If I had ipf I would try True North for several extended water fasts.
Gloria H.
Water fasting can't reverse scar tissue
Ali Houraibi
My father was diagnosed with IPF. Please more information about this matter
DJ Wilson
Do any of these posters ever get a response? from anyone?
Barbara A Schwenzer
Please.. how do I get on this study? Thank you!