AstraZeneca, BenevolentAI Identify New Treatment Target

AstraZeneca, BenevolentAI Identify New Treatment Target

AstraZeneca has added a novel target for idiopathic pulmonary fibrosis (IPF) to its portfolio, which was uncovered using BenevolentAI’s artificial intelligence-driven medication discovery platform. “The cause of IPF is largely unknown and the exact mechanisms involved in the progression of IPF remain elusive,” Anne Phelan, PhD, chief scientific…

Juggling Medications, Lab Tests, and Side Effects After Transplant

My pulmonologists are talented jugglers. They must determine my medication dosages, keep my lab results within the standard ranges, and minimize medication side effects. After my bilateral lung transplant in August 2020, it took a year to find the correct balance between all three. Medication baseline The balancing act started…

Autoantibody Reduction Regimen Improves Lungs, Survival: Study

An autoantibody reduction regimen that combines three treatments improved lung function and survival in adults with idiopathic pulmonary fibrosis (IPF) who are experiencing acute symptom worsening, a small study suggests. Early, positive clinical responses predicted better long-term outcomes, and high levels of autoantibodies against epithelial markers before treatment were…

Potential IPF Treatment AD-214 Works in Inhaled Form, AdAlta Says

AdAlta announced that AD-214, its candidate treatment for idiopathic pulmonary fibrosis (IPF), has been successfully made into an aerosol for inhalation — a nebulized form — while retaining the molecular properties that supported its potential effectiveness in preclinical studies. “The results of these studies support AD-214 being delivered by…

Pulmonary Rehabilitation for IPF as Effective as for COPD, Study Finds

Pulmonary rehabilitation is as effective a treatment for idiopathic pulmonary fibrosis (IPF) as it is for chronic obstructive pulmonary disease (COPD), a real-world study found. “Patients with IPF have similar completion rates and magnitude of response to pulmonary rehabilitation [to patients with COPD],” its scientists wrote. “These data reinforce the…

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