Idiopathic Pulmonary Fibrosis: Fibroblasts More Agresssive With USP13 Loss

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In a recent study entitled “Down-regulation of USP13 mediates phenotype transformation of fibroblasts in idiopathic pulmonary fibrosis,” a team of researchers investigated the differences in gene expression in fibroblast foci in patients with idiopathic pulmonary fibrosis (IPF). They found that the expression of a particular gene, USP13, was significantly decreased and associated with lower levels of a key tumor suppressor called PTEN. The team suggests that loss of PTEN enhances fibroblast aggressive behavior, contributing to IPF pathogenesis. The study was published in the journal Respiratory Research.

 

Read more: http://bit.ly/1OsOjgK

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