Funding Secured for Phase 1 Trial of Potential IPF Treatment LTI-03

Funding Secured for Phase 1 Trial of Potential IPF Treatment LTI-03

Lung Therapeutics announced that it has raised $36 million in Series C financing to fund two projects, including a healthy volunteer Phase 1 clinical trial testing LTI-03, an experimental therapy for idiopathic pulmonary fibrosis (IPF).

Currently approved therapies for IPF can slow disease progression, but cannot restore the lung function that has already been lost.

According to Lung Therapeutics, LTI-03 works differently from other pharmaceutical compounds, as it targets a cellular pathway known as the caveolin (Cav1) pathway. Caveolae (Latin for “little caves”) are small invaginations (folds) of the cell membrane, and Cav1 is a protein that plays a role in their formation.

In fibrotic conditions such as IPF, Cav1 protein is missing from fibroblasts — the cells that synthesize the extracellular matrix and collagen responsible for scarring (fibrosis). Thus, Cav1 seems to have a role in keeping fibrosis in check.

LTI-03 is a peptide containing a critical portion of Cav1. Experiments suggest that by adding LTI-03, lung fibroblasts can restore some of the lost balance, promoting normal extracellular matrix turnover — the process by which structural proteins such as collagen, elastin, and proteoglycans are degraded and new proteins are formed.

In experimental animal models of IPF, LTI-03 has been able to resolve lung injury when given 14 days after the induction of the disease. According to the company, LTI-03 has potent antifibrotic effects, and has potential in IPF treatment as it could be able to restore lung function, reversing the condition, and not just slowing disease progression.

The funding will also support the development of LTI-01, a potential therapy for patients with loculated pleural effusions, a serious complication of pneumonia.

“We are extremely thankful for the strong reception and support we have received from both our existing and new institutional investors. Both LTI-01  and LTI-03 show great promise to becoming new and beneficial therapeutic drugs for doctors and patients worldwide,” Brian Windsor, PhD, CEO of Lung Therapeutics, said in a press release.

“This financing will allow us to complete the first and only Phase 2 clinical trial in patients with loculated pleural effusions, as well as a healthy volunteer Phase 1 clinical trial for our second product candidate, LTI-03, which is in development for IPF patients,” Windsor said.

Alberto Molano was born in Bogotá, Colombia. He studied medicine at Universidad del Rosario and obtained a Ph.D. in Immunology from Weill Cornell Graduate School of Medical Sciences in New York. He conducted research and authored or co-authored twenty publications on molecular and cellular immunology, autoimmunity, immunology of aging and parasite immunology.
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Alberto Molano was born in Bogotá, Colombia. He studied medicine at Universidad del Rosario and obtained a Ph.D. in Immunology from Weill Cornell Graduate School of Medical Sciences in New York. He conducted research and authored or co-authored twenty publications on molecular and cellular immunology, autoimmunity, immunology of aging and parasite immunology.
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8 comments

    • Alberto Molano says:

      Please note that at this point it is only a Phase 1 trial reportedly involving healthy volunteers. The goal of Phase 1 trials is to determine the safety and toxicity of experimental medicines at different dose levels. In other words, the goal is not yet to determine the effectiveness of LTI-03.

  1. Diane Mosley says:

    How do we accepted into this trial? My husband has IPF and cannot tolerate OFEV. He is currently only on oxygen during exertion. At last scan he is mile to moderate stage.

  2. Sandie says:

    This sounds so promising! TY!TY!TY! for this research & effort. Hopefully it will be fast tracked & reach the many of us in desperate need of a miracle before its too late. We are praying for its success!

  3. Louise Vye says:

    What is the planned duration of this clinical trial? Also, what level of IPF diagnosis are you accepting?

  4. Betty Jones says:

    My husband has IPF. Takes 3 pirfenex 200 mg tablets 3 times a day. On oxygen. Diagnosed 10/17. Would like to be part of study.

  5. Sam Bilotta says:

    I’ve been diagnosed with IPF in July 2018.
    I live just north of Toronto Ontario Canada and have been on the OFEV treatment since Jan. 2019. I keep asking my Doctor if there is any clinical trials that I can participate in but she hasn’t come up with any yet. Is there any way that I can participate in this study.
    Thank You

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