Lindsey Shapiro, PhD,  science writer—

The U.S. Food and Drug Administration (FDA) has given GRI Bio the green light to conduct a Phase 2 trial of its investigational natural killer T-cell (NKT)-targeted therapy, GRI-0621, in people with idiopathic pulmonary fibrosis (IPF). With the clearance of its investigational new drug (IND) application, the company…

Treatment with AP01, Avalyn Pharma‘s experimental inhaled formulation of pirfenidone, appears to be slightly more effective for idiopathic pulmonary fibrosis (IPF) than the oral version, which is sold as Esbriet, and results in fewer side effects. AP01’s efficacy and safety profiles with progressive forms of pulmonary…

The first patients have been dosed in the Phase 2 REVERTIPF trial testing Tvardi Therapeutics’ investigational therapy TTI-101 in people with idiopathic pulmonary fibrosis (IPF). TTI-101 is an oral small molecule inhibitor of STAT3, a protein implicated in pulmonary fibrosis (PF), as well as certain types of cancer. The…

Scientists have developed a way to use engineered specialized stem cells to regenerate healthy airway tissues, offering a potential avenue for treating chronic lung diseases like pulmonary fibrosis (PF). In a pair of proof-of-concept preclinical studies published in Cell Stem Cell, scientists described how they engineered lung stem…

Suppressing the production of a protein called NPAS2 eased signs of lung scarring (fibrosis) in a mouse model of idiopathic pulmonary fibrosis (IPF), a new study showed. The NPAS2 gene, which codes for NPAS2, also was found to be more active in the lungs of IPF patients than in those…

Treatment with a molecule designed to activate the SHP-1 protein led to prolonged survival and alleviation of disease-associated lung changes in a mouse model of idiopathic pulmonary fibrosis (IPF), a study found. SHP-1 activation appeared to exert its protective effects by inhibiting the survival and pro-fibrotic activity of a…

The U.S. Food and Drug Administration has given the green light for Mabwell Therapeutics to launch a clinical trial testing 9MW3811, its injectable treatment candidate for idiopathic pulmonary fibrosis (IPF) and cancer, according to a company press release. Last month, the National Medical Products Administration in…

When used in a real-world setting, Ofev (nintedanib) significantly prolonged the survival of idiopathic pulmonary fibrosis (IPF) patients, according to an analysis of Czech registry data. Yet, Ofev was not associated with a significant slowing of lung function decline or with other estimations of disease progression. Findings were…

Dosing is now complete in the Phase 2b GALACTIC-1 trial of GB0139 for treating idiopathic pulmonary fibrosis (IPF). The trial, which finished enrolling participants about a year ago, is testing the safety and effectiveness of the inhaled treatment candidate against a placebo among IPF patients who are…

The dynamics of the extracellular matrix (ECM) that surrounds cells and gives structure to tissues may play an important role in the behavior of myofibroblasts, the connective tissue cells that are implicated in pulmonary fibrosis (PF), according to a recent study. “Our results underline the importance of the interactions…