Steve Bryson, PhD,  science writer—

Use of the well-known anticoagulant therapy warfarin in people with idiopathic pulmonary fibrosis (IPF) is associated with reduced transplant-free survival, but direct oral anticoagulants (DOACs) are not, a study found.  While…

A real-world analysis found that idiopathic pulmonary fibrosis (IPF) patients with preserved lung function benefitted from treatment with Ofev (nintedanib) and Esbriet (pirfenidone) over three years.  Despite untreated patients entering this study…

An inhaled formulation of nintedanib — the active ingredient in Ofev — demonstrated enhanced antifibrotic effects after short-duration doses compared to oral formulations given at a higher dose in a rat model with induced idiopathic pulmonary…

Ofev (nintedanib) is safe and effective for adults with idiopathic pulmonary fibrosis (IPF) with poorer lung function, a small real-world analysis has found.  Age and lung function predicted the therapy’s efficacy in this group of patients. …

Japanese people diagnosed with both pulmonary fibrosis (PF) and emphysema appear to carry a single genetic mutation that contributes to the development of both conditions, a study reports.  This mutation was linked to lower levels of the anti-inflammatory…

Adelmidrol therapy reduced markers for inflammation and oxidative stress, as well as tissue damage and collagen deposits, in the lungs of mice with pulmonary fibrosis (PF), a study has found. The findings support further investigation of adelmidrol as a…

Blocking an enzyme — called 15-PGDH — in a mouse model of pulmonary fibrosis (PF) limited early-stage inflammation and the development of fibrosis in the lungs, aiding the animals’ survival, a study demonstrated.  These findings support further work targeting 15-PGDH as a…

The protective tips of chromosomes, called telomeres, are shorter in men with idiopathic pulmonary fibrosis (IPF) than age-matched peers, and these changes seem to be linked to lower blood levels of the male hormone testosterone, a study reported. Further…

Rates of hospitalization and in-hospital mortality dropped significantly for people with idiopathic pulmonary fibrosis (IPF) in the U.S. between 2006 and 2016, and hospitalizations were most common in colder months, an analyses of disease trends found. The study, “Trends and…

Treating acute exacerbations with the protein thrombomodulin (ART-123) in idiopathic pulmonary fibrosis (IPF) patients may be associated with short-term survival benefits, a review analysis reports. However, larger studies are needed to confirm these findings, the researchers noted. The study, “Efficacy…