Treatment with GRI-0621, an experimental oral therapy from GRI Bio, boosts lung function in adults with idiopathic pulmonary fibrosis (IPF), according to top-line data from a Phase 2a clinical trial. The study (NCT06331624) met its primary goal, demonstrating no safety or tolerability concerns after 12 weeks of…
News
Building on positive Phase 2 data, Puretech Health plans to launch a Phase 3 trial in the coming months to further test its experimental oral therapy deupirfenidone (LYT-100) in people with idiopathic pulmonary fibrosis (IPF). “We are now advancing this pivotal program with urgency to bring forward a…
The U.S. Food and Drug Administration (FDA) has granted orphan drug designation to Birchbiomed’s FS2 (kynurenic acid) for the treatment of idiopathic pulmonary fibrosis (IPF). Orphan drug status is intended to incentivize the development of therapies for rare diseases — defined as those affecting fewer than 200,000 people in the…
A novel inhalable therapy has shown promise for treating idiopathic pulmonary fibrosis (IPF) by outperforming an approved oral medicine in a mouse study. The new treatment, called VB-RT NPs, consists of lipid nanoparticles loaded with two medicines, verteporfin and berbamine, designed to disrupt both the mechanical stiffness and biochemical…
The naturally occurring antioxidant alpha-lipoic acid, or ALA, which protects cells against the toxic effects of iron overload, may help reduce lung damage caused by silica — dust particles often found at construction sites and in mining — in pulmonary fibrosis (PF). That’s according to a study using lab-grown…
Treatment with Endeavor Biomedicines’ experimental oral therapy taladegib (ENV-101) improved lung function in people with idiopathic pulmonary fibrosis (IPF) in a Phase 2a clinical trial, newly published results show. “IPF has devastating effects on lung function, yet patients with this disease lack effective therapeutic options. Our Phase 2a…
The U.S. Food and Drug Administration (FDA) recently granted orphan drug designation to Calluna Pharma‘s CAL101 as a potential treatment for idiopathic pulmonary fibrosis (IPF). This designation is intended to incentivize the development of treatments for rare diseases that affect fewer than 200,000 people…
Blocking caspase-9 — an enzyme involved in programmed cell death, or apoptosis — may halt or reverse tissue scarring in pulmonary fibrosis (PF), according to a new preclinical study. Researchers found elevated levels of caspase-9 in lung tissue from people with PF and in a mouse model of the…
Software that uses artificial intelligence to analyze medical imaging tests may help facilitate earlier diagnosis and more accurate monitoring of pulmonary fibrosis in people with underlying lung diseases. Brainomix‘s e-Lung could allow doctors to detect progressive pulmonary fibrosis (PPF), where lung tissue becomes increasingly scarred and leads to…
Long-term treatment with deupirfenidone (LYT-100) is generally well tolerated and may stabilize lung function in people with idiopathic pulmonary fibrosis (IPF), according to new clinical trial data announced by the therapy’s developer, Puretech Health. Puretech has already met with the U.S. Food and Drug Administration to discuss the…
