Treatment with Genentech‘s FDA-approved Esbriet (pirfenidone) has been shown in two independent studies to improve moderate to more severe lung function impairment in patients with idiopathic pulmonary fibrosis (IPF). The results of the studies were recently presented at the American Thoracic Society International Conference (ATS 2017) May 19-24 in Washington,…
Prometic’s PBI-4050 leveled off idiopathic pulmonary fibrosis patients’ decline in lung function, indicating it is a promising treatment for the disease, according to a Phase 2 clinical trial. The leveling occurred when PBI-4050 was used by itself and when it was used in one of two combination therapies. IPF…
Bellerophon Therapeutics recently presented promising new data from two Phase 2 clinical trials investigating its product INOpulse in patients with pulmonary hypertension (PH) associated with idiopathic pulmonary fibrosis (IPF), and PH associated with chronic obstructive pulmonary disease (COPD) at the American Thoracic Society 113th International Conference (ATS 2017). The INOpulse device delivers inhaled nitric oxide…
Treatment with Galecto Biotech’s inhaled TD139 may become an effective and safe option for patients with idiopathic pulmonary fibrosis (IPF), according to a clinical trial conducted by Scotland’s University of Edinburgh. Galecto, a Danish pharmaceutical firm, will present the study’s findings at the American Thoracic Society 2017 International Conference…
The resokine protein reduced interstitial lung disease (ILD) in mice, according to one of two presentations that aTyr Pharma will make at the American Thoracic Society International Conference in Washington, which starts today. Atry derived its Resolaris therapy from resokine, which helps prevent the immune system from turning against healthy cells. Scientists…
Genoa Pharmaceuticals has completed a $62 million Series A financing round to pursue a Phase 2 clinical trial of Aerodone (inhaled pirfenidone) to treat idiopathic pulmonary fibrosis (IPF). The Seattle-based company also appointed Dr. Ketan Patel, Dr. Naveed Siddiqi, Tiba Aynechi, Niall O’Donnell and Dr. Heather Preston to its board of directors. Dr. Jonathan Leff,…
New York scientists have created a mini-lung in a laboratory that mimics a real lung’s response to a viral infection in pulmonary fibrosis. The mini-lung, which scientists call an organoid, will increase understanding of lung diseases, leading to better treatments, the researchers said. Dr. Hans-Willem Snoeck, a professor at Columbia University…
Researchers have identified 39 genes as critical to idiopathic pulmonary fibrosis (IPF), based on a computational analysis of large genomic studies. Their study, “Detecting the Molecular System Signatures of Idiopathic Pulmonary Fibrosis through Integrated Genomic Analysis,” appeared in the journal Scientific Reports. IPF patients do not respond to anti-inflammatory therapies such…
Veracyte will present new information supporting the use of its genomic tests to diagnose idiopathic pulmonary fibrosis (IPF) and lung cancer at the American Thoracic Society 2017 International Conference in Washington, May 19-24. The Envisia and Percepta Bronchial Genomic Classifiers were designed to reduce the need for diagnostic surgery and to…
The anti-inflammatory molecule protectin DX (PDX) has been shown to improve pulmonary fibrosis (PF) and lung function in mice, new research shows. The study, “Posttreatment with Protectin DX ameliorates bleomycin-induced pulmonary fibrosis and lung dysfunction in mice,” was published in the journal Scientific Reports. Lung fibrosis is characterized…
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