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IPF May Have a Specific Gene Signature, Aiding Potential New Therapies, Analysis Finds

Researchers have identified 39 genes as critical to idiopathic pulmonary fibrosis (IPF), based on a computational analysis of large genomic studies. Their study, “Detecting the Molecular System Signatures of Idiopathic Pulmonary Fibrosis through Integrated Genomic Analysis,” appeared in the journal Scientific Reports. IPF patients do not respond to anti-inflammatory therapies such…

Esbriet Lowers Risk of Respiratory Hospitalizations Among IPF Patients by Nearly Half, Study Finds

Besides its other benefits, Esbriet (pirfenidone) prevents respiratory-related hospitalizations in patients with idiopathic pulmonary fibrosis (IPF), according to a study examining data from more than 1,200 patients. Findings also showed that hospitalized patients who took Esbriet were less likely to die after one year. This effect decreased over time, though researchers…

Merger Creates Global Leader in Low-dose Carbon Monoxide Therapy for PF

Proterris and Alfama recently announced a merger of the two companies which will effectively create the world’s leader in the field of carbon monoxide (CO) therapies for acute and chronic diseases, such as pulmonary fibrosis. “The merger of Alfama with Proterris represents a very synergistic and strategic fit between two…

Bellerophon’s INOpulse Inhaled Nitrous Oxide Device Improves Symptoms of PH-IPF Patients, Study Finds

INOpulse has shown promise in treating patients with pulmonary hypertension associated with idiopathic pulmonary fibrosis (PH-IPF), concludes a study by Bellerophon Therapeutics, developer of the inhaled nitrous oxide device. The study, “Unraveling the Mode of Action of Pulsed Inhaled NO in Severe IPF Using Functional Respiratory Imaging.” showed that PH-IPF…

MRG-201 Reversed Fibrosis in Mice, miRagen Says in Report for Conference

MiRagen Therapeutics‘ MRG-201 has reversed fibrosis in mice with pulmonary fibrosis, according to a presentation the company prepared for the 76th annual meeting of the Society for Investigative Dermatology in Portland, Oregon. The biopharmaceutical firm develops fibrosis treatments that target microRNAs, small molecules that control whether genes are switched on or…