When used in a real-world setting, Ofev (nintedanib) significantly prolonged the survival of idiopathic pulmonary fibrosis (IPF) patients, according to an analysis of Czech registry data. Yet, Ofev was not associated with a significant slowing of lung function decline or with other estimations of disease progression. Findings were…
Brilaroxazine, Reviva Pharmaceuticals’ experimental therapy for idiopathic pulmonary fibrosis (IPF), was found to reduce lung inflammation and fibrosis, or scarring, in a rat model of the disease. The treatment also improved lung function and extended survival in the animals, the study showed. Titled “Evaluation of Brilaroxazine (RP5063)…
Cumberland Pharmaceuticals is launching a Phase 2 clinical trial to assess the safety and efficacy of its investigational therapy, ifetroban, in treating patients with idiopathic pulmonary fibrosis (IPF). The announcement follows the U.S. Food and Drug Administration (FDA)…
Dosing is now complete in the Phase 2b GALACTIC-1 trial of GB0139 for treating idiopathic pulmonary fibrosis (IPF). The trial, which finished enrolling participants about a year ago, is testing the safety and effectiveness of the inhaled treatment candidate against a placebo among IPF patients who are…
An experimental oral medication Bristol Myers Squibb is developing did better than a placebo at slowing lung function decline for up to 26 weeks, slightly more than six months, in people with idiopathic pulmonary fibrosis (IPF). The effect was seen when the therapy, BMS-986278, was given at a…
Researchers have discovered a variant of the usual basal stem cells found in the lungs that may contribute to scarring, or fibrosis, in people with idiopathic pulmonary fibrosis (IPF) — and which may be a therapeutic target to slow disease progression. The team found that these basal stem cells,…
patientMpower and Qureight have joined forces to accelerate the discovery of new prognostic markers for interstitial lung diseases (ILDs), a group of lung diseases characterized by scarring and inflammation that includes idiopathic pulmonary fibrosis (IPF). The collaboration will harness Qureight’s artificial intelligence (AI) capability along with patientMpower’s…
Dosing is complete in the Phase 3 REBUILD clinical trial testing INOpulse (inhaled nitric oxide) in people with pulmonary fibrosis at risk of developing pulmonary hypertension. In the blinded part of the study, which is now complete, participants were randomly assigned to receive nitric oxide or a placebo administered…
The Pulmonary Fibrosis Foundation (PFF) is urging patients to use only federally approved oxygen delivery devices, as nonprescription supplemental oxygen may be unreliable and cause serious health problems. In a position statement, the organization said that those living with pulmonary fibrosis (PF) and related disorders should stick…
The dynamics of the extracellular matrix (ECM) that surrounds cells and gives structure to tissues may play an important role in the behavior of myofibroblasts, the connective tissue cells that are implicated in pulmonary fibrosis (PF), according to a recent study. “Our results underline the importance of the interactions…
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