News

Aerobic Exercise Reduces Lung Fibrosis in Mice, Study Shows

Researchers have found, in mice with pulmonary fibrosis and with dominant immune response mediated by immune Th2 cells (T-helper cells), that aerobic exercise reduced lung fibrosis. The study, “Aerobic Exercise Attenuated Bleomycin-Induced Lung Fibrosis in Th2-Dominant Mice,” was published in the journal PLOS One. Fibrosis is the scarring and thickening…

Early Data Shows Benefits of Hypoxemia Treatment for IPF, Phase 2 Study Enrolling Patients

Global Blood Therapeutics (GBT) recently published positive preclinical results supporting the development of GBT440 for the treatment of lung diseases associated with hypoxemia (abnormally low levels of oxygen in the blood), such as idiopathic pulmonary fibrosis (IPF). The results were detailed in the study, “Increased hemoglobin–oxygen affinity ameliorates bleomycin‐induced hypoxemia…

Stem Cells from IPF Patients Used to Create Working 3-D ‘Lungs’ to Aid in Research, Personalized Treatment

Researchers used stem cells from patients with idiopathic pulmonary fibrosis (IPF) to create a lung “organoid” — a three-dimensional structure similar to the human lung — that stands to improve studies into lung diseases like IPF and research into personalized drug therapies, by allowing such investigations to take place in an environment…

AdAlta Hires FujiFilm to Produce Potential Therapeutic for IPF Patients

AdAlta, a biotech that develops protein-based therapeutics, has retained FujiFilm Diosynth Biotechnologies to manufacture AD-114, AdAlta’s lead drug molecule for the treatment of idiopathic pulmonary fibrosis (IPF). AdAlta is using its proprietary technology platform to create i-bodies, a new class of protein therapeutics that are the human equivalent of the antigen-binding domain…

Chronic Cough in IPF Patients Eased by Treatment in Phase 2 Study

Patara Pharma recently presented positive Phase 2 data on its lead candidate, PA101, for the treatment of refractory chronic cough in patients with idiopathic pulmonary fibrosis (IPF). The findings were given at the recent European Respiratory Society International Congress in London. PA101 is a late-stage immune modulator with mast…