A study from the University of Madras, India, showed that celastrol — a component of an extract from the Thunder God Vine root — was able to reduce inflammation, collagen deposition, and alveolar damage in a rat model of pulmonary fibrosis (PF). The effects were likely the result of a broad activation of…
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Researchers investigating pulmonary artery size in idiopathic pulmonary fibrosis (IPF) patients have found that the pulmonary artery:ascending aorta diameter (PA:A) ratio could predict IPF clinical outcome, representing a potential new tool for stratifying patients to identify those most at risk. The study, “Pulmonary artery size as a predictor of outcomes in idiopathic…
A Mayo Clinic study reported that patients with fibrotic interstitial lung disease are at a threefold higher risk of substantial morbidity when hospitalized for acute lung exacerbations, whether or not they have idiopathic pulmonary fibrosis (IPF). While the frequency and outcomes of acute respiratory exacerbations in IPF patients are rather well-documented, corresponding…
An interaction between cells in the lungs’ vasculature appears to spur tissue regeneration and is a potential target for therapies against fibrosis, according to a study titled “Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis,” published in the journal Nature Medicine. Lungs, as a result of their…
Genetic factors might drive at least part of the risk for idiopathic pulmonary fibrosis (IPF), particularly in familial forms of the disease, and a review from the Nanjing University School of Medicine, China, presented an updated view of genetic risk factors for IPF. The article, “Candidate genes of idiopathic pulmonary fibrosis:…
Researchers recently developed new nanoparticles more efficient at delivering in vivo (living) RNA interference (RNAi) for silencing pulmonary fibrosis-associated genes. The study entitled “Self-assembled Micelle Interfering RNA for Effective and Safe Targeting of Dysregulated Genes in Pulmonary Fibrosis” was published in the Journal of Biological Chemistry. RNAi, a natural…
A case study of a pulmonary fibrosis patient who was ultimately diagnosed with liver cirrhosis and a telomere length disorder, highlighted the need to consider whether short telomere syndrome is present in people with lung fibrosis and cirrhotic liver. The findings were published in the journal QJM: An International Journal…
Meet youtuber Kelly Patricia and watch her talk and explain how it is to live with an invisible illness. “I made this video in honor of all of us who are fighting invisible illnesses. I hope that this can have its own meaning to you. Always remember that…
A motor protein called myosin II was identified in a recent study to be a driver of fibrosis development — a finding with a notable potential to lead to improved treatments for idiopathic pulmonary fibrosis (IPF). The study by Cleveland Clinic researchers is titled “Matrix-Driven Myosin II Mediates the Pro-Fibrotic Fibroblast Phenotype,“ and was published in the …
Boehringer Ingelheim recently announced that OFEV (nintedanib) has been recommended by the National Institute for Health and Care Excellence (NICE) as a treatment for idiopathic pulmonary fibrosis (IPF) within the National Health Service (NHS) in England and in Wales. Nintedanib, an oral small molecule tyrosine kinase inhibitor, is recommended for…
