The key topics of discussion during a new webinar for people with pulmonary fibrosis (PF) focused on strategies — ranging from getting appropriate vaccines and managing individual symptoms to taking advantage of palliative and support care — for improving patient quality of life. The talk was given by Marlies…
CohBar has chosen CB5138-3 as its lead treatment candidate for idiopathic pulmonary fibrosis (IPF) and other fibrotic diseases, based on its promising safety, efficacy, and drug-like properties in preclinical studies. The company is planning to further test this peptide — a small protein fragment — in early studies…
Galecto was advised to stop enrolling and treating patients at high dose and certain ones at low dose in its Phase 2b GALACTIC-1 trial of GB0139, an investigational inhaled therapy for idiopathic pulmonary fibrosis (IPF). The recommendation — made by an independent data safety and monitoring board (DSMB) that…
Suppressing MDM4, a mechanosensitive protein produced by myofibroblasts — the main drivers of pulmonary fibrosis (PF) — promoted the death and clearance of myofibroblasts and reversed persistent lung scarring in a mouse model, a study shows. Notably, these benefits were associated with a reduced stiffness of the extracellular matrix (ECM),…
Tiny particles, or nanoparticles, coated with a peptide called GSE4 prevented some features of idiopathic pulmonary fibrosis (IPF) and eased others in a rat model of this disease, scientists report. No harmful effects were associated with the use of these GSE4-loaded nanoparticles in the animals, the team added, suggesting they should…
Exposure to certain work- and environment-related elements may be the cause of some idiopathic pulmonary fibrosis (IPF) cases, a recent meta-analysis shows. In particular, exposure to pesticides and agricultural work seem to be factors associated with an increased risk of a person developing IPF. Additionally, exposure to metal dust…
Many diseases have their own awareness color — breast cancer is pink, muscular dystrophy is green, and AIDS is red, for example — but what’s the significance of pink, green, blue, and purple lights side-by-side? These are the colors most often used to represent Rare Disease Day. This…
Respiratory viral and bacterial infections are common in people with idiopathic pulmonary fibrosis (IPF) and might play a role in the development of the disease, a study reported. The study, “The role of viral and bacterial infections in the pathogenesis of IPF: a systematic review and…
People should be reimbursed for costs of using Ofev (nintedanib) to treat progressive fibrosing interstitial lung diseases (PF-ILD), two agencies that help to guide health policy in Canada — the Canadian Agency for Drugs and Technologies in Health (CADTH) and the Institut national d’excellence en santé et services sociaux…
The first lung transplant using LUNGguard, a cold storage device for transporting donor lungs, was performed in a person with idiopathic pulmonary fibrosis (IPF), Paragonix Technologies, the device’s developer, announced. The first device of its kind to be cleared by the FDA, it became commercially available…
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