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    • #31768
      Amit
      Participant

      Has anyone tried serrapeptase, nattokinase and Ofev with any success?

      Also please could you let me know what strength of serrapeptase and nattokinase you’ve tried if it’s helped please?

    • #31799
      Denise Rousso
      Participant

      What are serraopeptase and nattokinase? I have tried Ofev, 150 mg X day, then reduced to 100 mgXday. Side effects of diarrhea. Have stopped it now temporarily.

      Denise Rousso

    • #31802
      Neha
      Participant

      Hi Amit, If it’s allowed on this forum, I’d like to share a small research study that looked at the effects of a 3 month supplementation of serrapeptase and nattokinase on people with PF. The treatment resulted in improved symptoms and quality of life in a majority of participants. Here is a link to the publication: https://www.mdpi.com/2305-6320/8/11/68

      Hope you are able to find something that helps.

      • #31814
        Amit
        Participant

        Hi Neha,

        Thank you so much for sharing this.

    • #31866
      Steve Dragoo
      Participant

      @amit,

      I have been taking both for years but far apart from each other. Serrapeptase knocked out almost all mucus 4.5 years ago and I rarely have a problem.  I take 720,000 SU’s daily far, far away from food and especially any other medications/supplements. I don’t take ofev or any script for IPF which at 73 (in May) and IPF since Oct 2016, I am thankful.

      Stay well,

      Steve

      • #31867
        Amit
        Participant

        Thanks for your reply and I’m so pleased you’re doing well.

        • For the serrapeptase do you take 720,000 SU all in one go daily?
        • For the nattokinase how much of this do you take and how often?
        • Is there anything else you take as I’m willing to try anything.
        • This reply was modified 2 months ago by Amit.
        • #31869
          Steve Dragoo
          Participant

          @amit

          Yes on the serrapeptase. Remember it dissolved protein which means it sees food and more importantly pills as protein and you do not want pills dissolving faster than they should. Had that happen once with metformin – wish it hadn’t happened.

          Natto 2000 FU with other pills and food – once per day in the AM – if you are on blood thinners – caution natto is a blood cleaner which can make it a little thinner – never had a problem.

          I take many things but diet water and starting the day right are vital. We start with a strong lemon Kalamansi over here with turmeric ginger honey olive oil and don’t eat or drink for 20+ minutes. Been doing it for years.

          You need to research on your own any supplements you are considering. I take D3 K2 Fish Oil, ALA, Co-Q10, NAC Berberine, B-complex, baby aspirin, and magnesium for supplements lots of water and metformin, Omerproazle and Androgel because my pituitary does not work.

        • #31870
          Amit
          Participant

          Thanks Steve,

           

          This is super helpful. Really appreciate you sharing what’s working for you.

        • #31871
          Steve Dragoo
          Participant

          There are a lot of foods to avoid that can help too.  But at my age I don’t worry about it that much and don’t eat a lot of meat anyways…

        • #31886
          Steve Dragoo
          Participant

          @amit,

          I forgot an important supplement many take and there is a white paper somewhere on the forum. It is EGCG. The first time it didn’t seem to help much. This time 18 months later it seems to have helped a lot.

          Another white paper about pterostilbene (basically blueberry concentrated a lot) was touted – took for a while but stopped because of my heart. Heart is better so I will try it again.

          Again there are many things I will try/do. One that helps is intermittent fasting (for autophagy and mitochondria increase).

          Hope these help you…

          Steve

        • #31888
          Amit
          Participant

          Thanks Steve, you’ve been so helpful sharing what works for you. I really do appreciate your kindness and raking the time to let me know.

        • #31901
          Ron
          Participant

          Where do you buy 720,000 of Serrapeptase?  Thank you

        • #31903
          Steve Dragoo
          Participant

          @trueswing

          Amazon 120,000 SU

      • #32023
        Christopher Leather
        Participant

        we have Nutra medix brand serrapeptase/ its 1000 mg per capsule. Which brand are you using`? and natto ? ever try eating natto? think one would need to eat quite a bit to get to a good fibrin eating one!

        anyone use wobenzym? Saw good write up from 2005

        Much thanks!

        • #32030
          Steve Dragoo
          Participant

          @christopher194678
          Hi – if you were asking me, it helps if you use the screen name so I would get alerted.

          Serrapeptase is measured in SU if anything else is with it, it is a waste of money. Both the serra and natto I usually buy through Amazon and no I don’t eat natto but take it daily with breakfast.  Hope that helps.

          Stay well…
          Steve

    • #31910
      Linda
      Participant

      My husband takes ofev 2x a day. He had some diarrhea but we think is was because of having dental work with a lot of antibiotics. So far he’s doing good again. Never heard of those other two meds

    • #31911
      Linda
      Participant

      Has anyone had luck with taking just ofev?

    • #31934
      Millie
      Participant

      I was taking serrapeptased but stopped it to begin ofev. It seems that they are both blood thinners and I was afraid to be taking both at the same time. I liked serrapeptase very much for it’s scar dissolving ability. My doctor never heard of serrapeptase. I was also doing deep tissue massage on my back plus cupping. My dose was 80,000 u 3 times a day. Has anyone taken both at the same time with no ill effects. I’d like to hear about it. I only took this for 6 weeks—-so not enough time to evaluate its success. I would say 6 months would be a better timeframe.

      • #31937
        Steve Dragoo
        Participant

        @zebra4018

        Hi Millie,

        Serrapeptase is a blood cleanser and is not a blood thinner but you always want to error on the safe side because it should never be taken anywhere close to other pills or food. I don’t know the impact or interactions with meds that slowly dissipate in the body.

        Stay well,

        Steve

        • #31943
          Millie
          Participant

          My pulmonologist knows nothing about it. Dr Axe, a naturopath, says it may increase the risk for bruising and bleeding especially when taken with a known blood thinner which ofev is. What is your source of information on this? Does anyone else have any comments or knowledge.

        • #31963
          Steve Dragoo
          Participant

          Dr Axe is not somebody I follow and you can search the net for a wide variety of responses but after using Serrapeptase 4.5 years very successfully I am glad I discovered it.

          Remember that almost all cautions I have read use the word “may” cause – whatever… Similar to an attorney doing a basic CYA. You must decide for yourself and when I started I was concerned so I started with a much lower dose. My reasoning is simple, IPF will kill me anyway and at 73 I am willing to test out the research I do on myself.

        • #32019
          Diane B
          Participant

          Oh boy…thanks for sharing that.  I had my husband start taking the serrapeptase , I think, back in 2016.  I think I had been taking it even before then, but I forget what for.  I think he takes it in the a.m. with his other meds. I keep hearing of cough and mucus and until just recently he has never had mucus issues…a cough sometimes but not at night when he is asleep.  He takes a bunch of stuff along with OFEV.

    • #31968
      Millie
      Participant

      I didn’t realize you were using it for that length of time. Please don’t be so defensive. I’m searching for reliable information on this. Dr. Axe is a well-known and widely respected doctor. Do you use the serrapeptase in combination with the ofiv? That, for me, can be the game changer. If so, what is your dose of the serrapeptase? I was doing the deep tissue massage on my back and the cupping on my back because they, also, help break up scar tissue. It was my little experiment to provide a little bit of a kick to the serrapeptase. Some things are a little scary for me because I’ve never been sick or had any major illnes until this.

      • #31978
        Steve Dragoo
        Participant

        @zebra4018

        Millie,

        I have no idea what you are talking about – defensive. All I have done is try my best to be specific and direct because anything we try can be risky. I am aware of Axe and many other doctors that I do review but my opinion is to collect all the useful information I can and make a decision on what I know.  Also for safety and updates, I generally review all the stuff I take about twice per year.

        These forums have been invaluable in new discoveries and you may want to look at those on using a laser as well. I did until I came to the Philippines and still would but they don’t have the right type here in this country and I had the director of the Medical Missionary school we graduated from search for me as he is a native and very well connected.

        I mentioned in earlier posts I don’t take Ofev. But if I was stateside I would look into Esbriet – light dose with my VA pulmonologist. Serrapeptase I started slow but it worked so (surprising) fast in my case that after reading several articles there are no real contraindications up to 1,000,000 SU. I started at about 240,000 SU and have gone as high as 840,000 SU when I was suffering from an acute exacerbation, for the last several months 720,000 SU.

        Since I am 73 next Saturday and more than 5.5 years into IPF (and other issues because of IPF and other illnesses), I will try anything I can vet properly.

        Stay well,
        Steve

        • #31993
          Millie
          Participant

          This is for you, Steve. After taking serrapeptase for over 5 years, have you found that it has reduced the scarring in your lungs? I went off the serrapeptase after 6 weeks because I had the opportunity to try ofev free of charge. It is a very expensive rx otherwise. I need to give it at least 6 months or until my pulmonologist does another scan to see how it is working for me. In my case, time is of the essence. I had this PF without symptoms for at least 3 years before I became aware of it. I am old and feel that I don’t have a lot of time to play around with experiments of my own doing. Would love to but as we all know, we have to make tough decisions and do what we think is in our best interest.

        • #32004
          Steve Dragoo
          Participant

          @zebra4018

          Millie, I have taken serra 4.5 years so far and there is no direct evidence I am aware of that it reduces lung scar tissue – other scar tissue probably according to a couple of white papers I have seen.

          If I was on Ofev or Esbriet, I would not stop taking serra but that is just me at 73 and little to lose in trying at this point, not a recommendation (disclosure)…

          Stay well,
          Steve

        • #32008
          Millie
          Participant

          So what is the benefit of serrapeptase for you? You also take another enzyme, don’t you. It starts with the letter “n.”

        • #32021
          Steve Dragoo
          Participant

          Serr knocks out my mucus and nattokinase is a blood cleaner.

    • #31979
      Steve Dragoo
      Participant

      @zebra4018

      “A merry heart makes a cheerful countenance, but by sorrow of the heart the spirit is broken.”…

      • #31987
        Millie
        Participant

        That is where my concern lies-taking both ofev and serrapeptase together. Is there anyone out there who does this. Please let me know if you do and if you’ve had problems from doing so. Thanks for the info Steve. You have ben very helpful.

        • #32010
          Neha
          Participant

          Hi Millie, our non profit, Pulmonary Fibrosis NOW!, has an ongoing clinical study  examining the effects of serrapeptase and nattokinase in people with IPF. A majority of the participants enrolled were already taking esbriet or ofev. All patients are under the care of their pulmonologist and so far we have not had any patient discontinue due to drug interactions or side effects. I must add that the enzyme supplements are taken on an empty stomach either 2 hours after or 1 hour before their meal and/or other medications. We will be happy to share the results on this forum once the study is completed and published, hopefully by the end of this year. Meanwhile, hope you are able to find something that works for you and helps you.

          • This reply was modified 1 month, 3 weeks ago by Neha.
    • #32013
      Donald Salzberg MD
      Participant

      Hello

      I had looked into Serrapeptase (SP) in the past. I’m on OFEV 150mg 2x/day for 3.5 years and very stable on HDCT/PFTs. SP is totally broken down by the stomach unless it is enteric-coated, otherwise likely useless. Recommended dosage is 10-60 mg/day (20,000-120,000 units).  Very little evidence it’s helpful for ⬇️Pulmonary Fibrosis. Lots of warnings for those with liver issues and those on blood thinners, fish oil, aspirin etc. Best to take on an empty stomach. What interests me is the potential to reduce mucus which makes me quite hoarse. As a physician our Hippocratic oath is “do no harm.” Steve I would just recommend keeping a close look at your LFTs (liver function tests). Does anybody know which brand (s) of Serrapeptase are enteric-coated? I’m considering this b/o mucous.   Everybody’s IPF progresses at their own rate but CLEARLY OFEV & Perfenidone slow down the rate of progression. Good luck out there. I may give SP a try.

      Don Salzberg MD

    • #32014
      Scott B Burns
      Participant

      I have been using both daily for 4 years.

    • #32016
      Linda
      Participant

      So you are taking all 3 and doing ok

    • #32018
      Will Gale
      Participant

      Hi I am 85 years of age and was lass year June 2021 diagnosed with IPF and immediately placed on Olev 150mg twice per day. All seemed well until November 2021 when I noticed a distinct lack of appetite and intense body itching which was treated with antibiotic cream. By January I was totally lacking appetite and frequently vomiting Dr reduced dosage to 100mg twice day and ordered blood tests alarm set in when the blood test revealed that my liver function was being attacked the GGT level had risen from regular 35mm/ to 350mm/. the Dr ordered the cessation of Olev and at present my GGT levels have reduced to 150mm/. I have got my appertite back and am feeling quite well, my breathing function has been checked and I am on a nightly breathing assist mask. Will return to Dr at end of June but at this stage thing I will give Olev a miss as the cure is worse than the disease. Will Gale

    • #32020
      Diane B
      Participant

      I purchase serra for my husband.  I believe it is Doctors Best.  I am thinking he goes back and forth between 120,000 and 240,000.  Im not sure.  He takes both OFEV and serra .  Has been on  serra for several yrs. now.  OFEV maybe a yr or two.

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