The U.S. Food and Drug Administration (FDA) recently granted orphan drug designation to Calluna Pharma‘s CAL101 as a potential treatment for idiopathic pulmonary fibrosis (IPF). This designation is intended to incentivize the development of treatments for rare diseases that affect fewer than 200,000 people…
Therapy targeting lung scar tissue gains important FDA designation
“Ready to get that tube out? Sam, are you ready to get that tube out? Are you in any pain? No. Are you ready to breathe on your own?” Those were among the first words I heard as my wife, Susan, sat at my bedside while my care team brought…
Less than a year after my husband, Donnie, was diagnosed with pulmonary fibrosis, we decided to take a road trip to the suburbs of Denver to attend a memorial service for a close family friend. His family had invited us to stay for a few days, and we decided…
Blocking caspase-9 — an enzyme involved in programmed cell death, or apoptosis — may halt or reverse tissue scarring in pulmonary fibrosis (PF), according to a new preclinical study. Researchers found elevated levels of caspase-9 in lung tissue from people with PF and in a mouse model of the…
Water is essential to life. As UC Davis Health notes, it’s “vital to our health. It plays a key role in many of our body’s functions, including bringing nutrients to cells, getting rid of wastes, protecting joints and organs, and maintaining body temperature.” However, the source of the water we…
Software that uses artificial intelligence to analyze medical imaging tests may help facilitate earlier diagnosis and more accurate monitoring of pulmonary fibrosis in people with underlying lung diseases. Brainomix‘s e-Lung could allow doctors to detect progressive pulmonary fibrosis (PPF), where lung tissue becomes increasingly scarred and leads to…
For the first time in more than 10 years, idiopathic pulmonary fibrosis (IPF) care teams and patients will have a new treatment option following the Oct. 7 approval of Jascayd (nerandomilast) by the U.S. Food and Drug Administration (FDA). When I was diagnosed with IPF in January 2017,…
When my husband, Donnie, started exhibiting concerning symptoms in early 2021, we initially attributed it to a lack of exercise during the pandemic or possibly long COVID-19. The initial shortness of breath he experienced seemed innocent enough, so he shrugged it off as a reminder that he probably needed to…
Long-term treatment with deupirfenidone (LYT-100) is generally well tolerated and may stabilize lung function in people with idiopathic pulmonary fibrosis (IPF), according to new clinical trial data announced by the therapy’s developer, Puretech Health. Puretech has already met with the U.S. Food and Drug Administration to discuss the…
Vaccines are a routine part of the pulmonary fibrosis (PF) journey, regardless of where you are along the path. However, recent changes in vaccine guidance from the U.S. Centers for Disease Control and Prevention (CDC) have caused some confusion. When I was diagnosed with idiopathic pulmonary…
