Pharmaxis Ltd. and Synairgen plc are entering into a research collaboration to develop a therapeutic for idiopathic pulmonary fibrosis (IPF). The two companies are researching a selective inhibitor of the lysyl oxidase type 2 enzyme (LOXL2), an enzyme shown to promote scar tissue and damage in the lungs of IPF…
Pharmaxis and Synairgen Collaborate on LOXL2 Inhibitor to Treat IPF
An accumulation of data from multiple different studies supports the use of pirfenidone (Esbriet, from Roche) to treat idiopathic pulmonary fibrosis. One study in Belgium and the Netherlands demonstrated strong safety and efficacy profiles, and two more studies in the United States suggested a reduction in disease progression following treatment.
Moerae Matrix Inc. recently announced the start of a second Phase 1 clinical trial with MMI-0100, a therapeutic drug developed for pulmonary disorders associated with fibrosis and inflammation, as is the case with idiopathic pulmonary fibrosis (IPF). IPF is a progressive fatal lung disease in which the alveoli and the…
A new study led by researchers at the Comprehensive Pneumology Center (CPC) at Helmholtz Zentrum Munich in Germany recently revealed a new mechanism that contributes to the development of idiopathic pulmonary fibrosis (IPF). The study is entitled “Regulation of 26S Proteasome Activity in Pulmonary Fibrosis” and…
A new study recently published in the journal Respirology reviewed the growing evidence of a link between cigarette smoking and the development of interstitial lung diseases (ILD) including idiopathic pulmonary fibrosis (IPF). The study is entitled “Smoking-related idiopathic interstitial pneumonia: A review” and was developed…
Pulmatrix, Inc. a clinical stage biopharmaceutical company developing innovative inhaled therapies to address serious pulmonary disease using its patented iSPERSE™ technology, has been granted two patents from the U.S. Patent and Trademark Office, covering the composition of matter for iSPERSE™ as well as methods for treating patients using respirable dry…
MediciNova, Inc., a publicly-traded biopharmaceutical company working on developing novel, small-molecule therapeutics for the treatment of diseases with unmet medical needs, recently announced that it is in late-stage discussions with researchers at Penn State University (lead researcher Dr. Rebecca Bascom) to begin a Phase 2 clinical trial of MN-001 (tipelukast) for…
A protein expressed solely by cells lining the airways is at the center of an interesting new strategy that may help fight pulmonary fibrosis. The protein, secretoglobin (SCGB) 3A2, was investigated during a recent study conducted by the Laboratory of Metabolism at the National Cancer Institutes in the National Institutes of…
The Medical University of South Carolina (MUSC) and Bristol-Myers Squibb Company have announced their joint entry into a translational research collaboration focused on fibrotic diseases, including scleroderma, renal fibrosis and idiopathic pulmonary fibrosis (IPF). Under the agreement, studies designed to improve the mechanistic understanding of fibrosis, explore patient…
Boehringer Ingelheim recently announced that it welcomes the international evidence-based 2015 ATS/ERS/JRS/ALAT Clinical Practice Guideline: Treatment of Idiopathic Pulmonary Fibrosis – An Update of the 2011 Guideline, as it suggests the use of OFEV (nintedanib) in patients with idiopathic pulmonary fibrosis (IPF). This recommendation directed to clinicians is considered…
