Mechanism to Ease Lung Infection

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Researchers reported a novel role for a receptor at the surface of macrophages (specialized cells of the immune system) in lung fibrosis resolution. The study, titled “TRPV4 Mechanosensitive Ion Channel Regulates LPS-Stimulated Macrophage Phagocytosis,” was published in the Journal of Immunology.

Altogether, the results suggest that the TRPV4 channel can help clear lung infections and contribute to the resolution of infection-related lung injury in lung diseases, such as pulmonary fibrosis (PF). These findings may have implications in the development of new therapeutics for lung defense against infections and infection-associated fibrosis.

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