Author Archives: Forest Ray PhD

Spred2 Gene Plays Possible Role in PF Development, Mouse Study Finds

A protein-coding gene called Spred2 may contribute to pulmonary fibrosis (PF) development, potentially representing a new therapeutic target, according to the results of a new study. Titled “Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin,” the study was…

ATS Offering Total of $150K for Research Into IPF, Asthma, COPD

The American Thoracic Society (ATS) Research Program and 4DMedical are offering three one-year, $50,000 grants for research into idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), and asthma. “These three grants are a welcome addition to the ATS Research Program,” said MeiLan Han, MD,…

TL1A Protein and Its Receptor Drive Lung Fibrosis, Study Finds

A protein called TL1A drives fibrosis in diseases such as idiopathic pulmonary fibrosis (IPF), asthma, and systemic sclerosis by interacting with a receptor called DR3, a study reports. Disrupting this interaction might prevent the formation of fibrotic tissue. These findings are described in the study “TL1A…

Inhaled GB0139 for IPF Named Orphan Drug in US and EU

Galecto‘s investigational compound GB0139, now in an enrolling clinical trial, has been designated an orphan drug by the U.S. Food and Drug Administration and the European Medicines Agency (EMA) as a potential treatment of idiopathic pulmonary fibrosis (IPF). GB0139 (formerly TD139) is an inhaled small molecule inhibitor of…