News

An evaluation of 52 gene profiles in blood samples can help predict the clinical outcome of patients with idiopathic pulmonary fibrosis (IPF), finds a study published in The Lancet Respiratory Medicine. If confirmed in future studies, this gene expression profile evaluation could improve currently used outcome measures, as well as IPF patient…

A post-hoc analysis of data from Phase 3 studies shows that Esbriet (pirfenidone) can significantly reduce the incidence of disease progression events in people with idiopathic pulmonary fibrosis (IPF) — including respiratory-related hospitalizations, decline in lung function and physical capacity, and the risk of death — compared to placebo. These results…

PMD Healthcare is among the companies and groups marking Pulmonary Fibrosis Month, and supporting efforts to raise awareness of pulmonary fibrosis (PF) and improve the care of people with this disease. PF Month, which runs through September, stems from an initiative created by the Pulmonary Fibrosis Foundation (PFF) to  educate the…

Boehringer Ingelheim has joined idiopathic pulmonary fibrosis experts and patient advocacy groups to raise awareness of the early signs and symptoms of the disease. To help mark IPF World Week from Sept. 16 to 24, the company has created several educational tools to help doctors identify the characteristics of IPF…

The latest Phase 2 trial results of the investigative therapy Pamrevlumab in patients with idiopathic pulmonary fibrosis (IPF) further demonstrated the drug’s therapeutic potential to reduce fibrosis progression and ameliorate IPF clinical manifestations, with no reported adverse toxicity. So concludes an oral presentation, “RAISE, a randomized, placebo-controlled, double-blind Phase 2 clinical…

An inhaled version of miRagen Therapeutics‘ potential fibrosis therapy MRG-201 rendered genes involved in scarring nearly inactive in a rat model of lung fibrosis, the company reported. The preclinical-trial study also showed that most of the compound reached the animals’ lungs. The fact that little of it was found in other tissue…

Scientists at the University of Pennsylvania identified two populations of lung mesenchymal cells that may play a distinct role such in diseases as pulmonary fibrosis — one that seems to protect against disease and the other possibly promoting it when things go awry. Results suggest that future therapies targeting each cell type…

Synairgen and Pharmaxis are preparing a Phase 1 clinical trial of PXS-5382A for pulmonary fibrosis and other tissue-scarring disorders. Positive results of preclinical-trial studies on the therapy’s pharmacology — the way it works — and toxicology paved the way for the trial, the company said. PXS-5382A blocks an enzyme known…

A combination of Ofev (nintedanib) and Esbriet (pirfenidone) is as safe a therapy for idiopathic pulmonary fibrosis as the individual components alone, a Phase 4 clinical trial indicates. Preliminary trial findings also suggested that the combination might be more effective than either therapy alone, although researchers said this needs to…

Boehringer Ingelheim has extended its collaboration with Inventiva on developing treatments for tissue-scarring conditions such as idiopathic pulmonary fibrosis, or IPF. The company exercised an option to continue the partnership, which began in 2016. A joint research team has identified a target for a fibrosis therapy, and preliminary results indicate…