High-dose AP01 (inhaled pirfenidone) largely prevented lung function decline and was safe and well-tolerated during the first 24 weeks of a Phase 1/2 clinical study testing its use in patients with idiopathic pulmonary fibrosis (IPF). Avalyn Pharma, the therapy’s developer, presented the results at the 2021…
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As part of the worldwide commemoration of Clinical Trials Day, held each year on May 20, the Pulmonary Fibrosis Foundation (PFF) is urging people with pulmonary fibrosis (PF) to join ongoing clinical studies. In its call for participants, the PFF highlighted how patient involvement is the “most important…
Idiopathic pulmonary fibrosis (IPF) patients showing greater changes in blood cell ratios often used as markers of inflammation are at higher risk of lung function decline, respiratory hospitalization, and death, according to a post-hoc analysis of data from several Phase 3 clinical trials. Notably, these associations were more pronounced…
People with idiopathic pulmonary fibrosis (IPF) who live in poorer neighborhoods are less likely to receive a lung transplant and have a higher mortality risk, a U.S. single-center study reports. The study’s lead researcher said she was surprised the findings of “neighborhood-level disadvantage” reached significance given the relatively…
Veracyte has presented new data demonstrating the diagnostic performance and utility of its Envisia Genomic Classifier to help distinguish idiopathic pulmonary fibrosis (IPF) from other interstitial lung diseases (ILDs). The company is now…
While receiving treatment at specialized centers lowers the risk of hospitalization among patients with idiopathic pulmonary fibrosis (IPF), being a former smoker and requiring oxygen therapy are both associated with a higher likelihood of hospitalization. These are some of the findings of multiple studies that Boehringer Ingelheim will…
Algernon Pharmaceuticals has announced that its Phase 2 trial of oral NP-120 (ifenprodil) in treating chronic cough associated with idiopathic pulmonary fibrosis (IPF) has reached 50% of its enrollment target. The proof-of-concept and open-label study (NCT04318704), currently underway at four sites in Australia and two in New…
Magnesium lithospermate B, a compound found in a traditional Chinese medicinal herb, eased several features of pulmonary fibrosis (PF) in a mouse model of the disorder. According to investigators, the anti-fibrotic effects of this plant compound were comparable to those of Esbriet (pirfenidone), an approved treatment for…
In a move that refocuses its clinical pipeline, Galapagos is discontinuing the development of GLPG1205, its experimental therapy for idiopathic pulmonary fibrosis (IPF), and advancing its most recent IPF candidate, GLPG4617, into a Phase 2 clinical trial. These and other decisions toward a “more risk-balanced pipeline” are…
Vicore Pharma and Alex Therapeutics are collaborating to develop a new phone app that could help improve the mental health of people with idiopathic pulmonary fibrosis (IPF). Vicore will own all rights to the new clinical program, called VP04, in exchange for various payments and royalties to…
