Blocking an enzyme — called 15-PGDH — in a mouse model of pulmonary fibrosis (PF) limited early-stage inflammation and the development of fibrosis in the lungs, aiding the animals’ survival, a study demonstrated. These findings support further work targeting 15-PGDH as a…
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Conditions affecting the heart, stomach, and esophagus occur more frequently in patients whose diagnosis of idiopathic pulmonary fibrosis (IPF) is delayed, coming more than one year after the onset of symptoms, according to a recent study. This delayed diagnosis seems, however, to have no impact on the risk of…
A three-year pulmonary rehabilitation program — a combination of aerobic, resistance, and breathing exercises — helped to maintain lung and muscle strength before a double-lung transplant in a middle-aged man with idiopathic pulmonary fibrosis (IPF) and a sedentary lifestyle, a case study reports. The study “Long-Term…
Biognosys and Boehringer Ingelheim are working together to expand the use of cutting-edge technologies for large-scale protein analysis in drug discovery, beginning with a study of potential new treatment approaches to idiopathic pulmonary fibrosis (IPF). Biognosys announced that it will bring its expertise in proteomics — the…
Exposure to secondhand smoke, dust, or asbestos in the workplace is linked to a significantly higher risk of developing idiopathic pulmonary fibrosis (IPF), according to findings of an Australian study. These results suggest that “the burden of IPF could be reduced by intensified tobacco control, occupational dust control measures…
Failure of organs other than the lungs can be a predictor of mortality risk in people hospitalized due to acute exacerbations of idiopathic pulmonary fibrosis (IPF), a study reported. Elevated levels of C-reactive protein, a sign of inflammation, is also a risk factor for in-hospital mortality in these patients.
Scientists created an online cell atlas containing information on the gene activity of more than 300,000 lung cells taken from patients with idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). The new atlas adds to the knowledge of the complex cellular and molecular mechanisms involved…
Researchers have discovered the existence of unique subtypes of epithelial cells in the lungs of people with pulmonary fibrosis (PF) that may drive tissue scarring, or fibrosis. Their findings were published in the study, “Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary…
The European Commission has approved Boehringer Ingelheim‘s Ofev (nintedanib) for the treatment of progressive fibrosing interstitial lung diseases (ILDs) in adults. The approval follows a recent positive opinion from the Committee for Medicinal Products for Human Use (CHMP), as well as…
The protein granulocyte-colony stimulating factor (G-CSF) inhibited fibrosis in a mouse model of pulmonary fibrosis, a new study shows. The data suggests this effect is driven, in part, by stem cells from the bone marrow being recruited to the lungs. The study, “G-CSF Inhibits Pulmonary…
