Research and Development
This group unites PF patients, caregivers, researchers and medical professionals in a platform to... View more
Organizer:
- Organized by
-
-
Chemical in Vegetables Displays Anti-Fibrotic Activity in Lung Tissue, Study Reports
-
Chemical in Vegetables Displays Anti-Fibrotic Activity in Lung Tissue, Study Reports
A chemical found in certain types of vegetables displayed anti-tissue scarring activity in laboratory and mice lung-tissue experiments, a study reports.
The results suggested that the chemical, sulforaphane, could be used to treat idiopathic pulmonary fibrosis, or IPF, researchers said.
An article about the study, “Sulforaphane attenuates pulmonary fibrosis by inhibiting the epithelial-mesenchymal transition,” appeared in the journal BMC Pharmacology & Toxicology.
Patients with IPF, a progressive and chronic lung disease, have high levels of cells known as fibroblasts and myofibroblasts that can lead to lung tissue scarring — or fibrosis — and respiratory failure.
Epithelial cells in the lung can transition into fibroblasts or myofibroblasts through a process known as epithelial-mesenchymal transition, or EMT. This means that targeting EMT could be a way to treat IPF.
Sulphoraphane is found in cruciferous vegetables, which include broccoli, cauliflower, Brussels sprouts, kale, cabbage, and bok choy. The chemical can regulate signaling pathways associated with EMT, cancer studies have shown. In addition, research has demonstrated that it has anti-fibrotic activity in the liver.
Read more about it here: “Chemical in Vegetables Displays Anti-Fibrotic Activity in Lung Tissue, Study Reports“
-
0 Replies
Sorry, there were no replies found.
Log in to reply.