A new mobile app called PF Health has been launched to help patients with pulmonary fibrosis track their symptoms and share that information with their healthcare providers. The PF Health app resulted from collaborative work of the Pulmonary Fibrosis Foundation (PFF) and monARC Bionetworks, and aims to empower…
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Targeting a key protein of the innate immune system called TLR4 could be a new way of treating people with pulmonary fibrosis (PF) and other fibrotic disorders, according to a Northwestern University study. The study, “TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung,” was published…
Blade Therapeutics has launched a Phase 1 clinical trial to evaluate BLD-2660, its lead therapy candidate for the treatment of fibrosis, the company recently announced. The randomized, placebo-controlled, dose-escalation Phase 1 trial (NCT03559166) is enrolling an estimated 88 healthy volunteers to assess the safety and pharmacokinetics — how…
Pliant Therapeutics raised $62 million in a second round of financing that will be used to support the development of the company’s lead product candidates in fibrotic diseases. The funding is expected to advance therapies to early-stage clinical trials in idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis…
Galapagos is planning to launch a Phase 2 clinical trial for its treatment candidate GLPG1205 in patients with idiopathic pulmonary fibrosis (IPF). Expected to begin in the second half of 2018, the PINTA trial will evaluate the safety and effectiveness of this investigational therapy at several clinical sites in…
Pulmonary fibrosis (PF) and other lung diseases may be late complications in patients with Type 2 diabetes, according to a German study. The study, “Breathlessness and Restrictive Lung Disease: An Important Diabetes-Related Feature in Patients with Type 2 Diabetes,” was published in the journal Respiration. Breathlessness…
NuMedii will collaborate with researchers at Yale School of Medicine and Brigham and Women’s Hospital to develop precision therapies and biomarkers for idiopathic pulmonary fibrosis (IPF). Under this strategic research collaboration, the company will work with teams of two leading experts in interstitial lung disease: Naftali Kaminski, MD, a…
A man with idiopathic pulmonary fibrosis (IPF) was kept alive and his blood oxygenated for more than a year while waiting for a lung transplant using a type of extracorporeal membrane oxygenation (ECMO) called veno-venous ECMO — a procedure usually limited in use to about two weeks, researchers in Japan report. They estimate that one…
Astragaloside IV — a compound isolated from a traditional Chinese medicinal plant — was found to reverse epithelial–mesenchymal transition, a process crucial to the progression of fibrosis, through its impact on a protein called FOXO3a, a study by researchers in China reports. The study, “Astragaloside IV modulates TGF-b1-dependent epithelial-mesenchymal…
The introduction of bias in the design and analysis of studies likely explains a reported reduction of mortality with antacid therapy in patients with idiopathic pulmonary fibrosis (IPF), according to a new Canadian review study. The research, “The effect of anti-acid therapy on survival in idiopathic…
