Low body mass index (BMI) is a risk factor for nausea and diarrhea as side effects of Ofev (nintedanib) treatment in patients with idiopathic pulmonary fibrosis (IPF), a study has found. These results also suggest that lower performance status and a full starting dosage are risk factors…
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Imagine living your whole life with a painful disease so rare that only 25 others worldwide have what you have. And that you’re one of just six such people who’ve made it to adulthood. Neena Nizar doesn’t have to imagine. The 41-year-old English professor at Metro Community College in Elkhorn,…
Impaired autophagy — cells’ self-cleansing process — in the lungs’ epithelial cells may activate their epithelial-mesenchymal transition (EMT), a process crucial to the progression of fibrosis, according to a new study. The finding suggests that therapies targeting EMT may help halt fibrosis in idiopathic pulmonary fibrosis (IPF). The study, “…
N115, EmphyCorp‘s investigational non-steroidal nasal spray for the treatment of interstitial lung diseases (ILDs), has completed a Phase 3 clinical trial requested by the U.S. Food and Drug Administration (FDA) for its new drug application (NDA) in patients with pulmonary fibrosis (PF). EmphyCorp’s proprietary…
Taking Esbriet (pirfenidone) to manage idiopathic pulmonary fibrosis (IPF) does not increase the risk of heart problems or interfere with commonly used cardiovascular medications, an analysis found. Results of the analysis were published in the journal Advances In Therapy in an article titled, “Cardiovascular Risks,…
People with idiopathic pulmonary fibrosis (IPF) and right heart dysfunction may benefit more from a therapy combining Ofev (nintedanib) with sildenafil than from Ofev alone in terms of cardiac health, according to data from a Phase 3 study. The study, “Nintedanib and Sildenafil in Patients with Idiopathic Pulmonary…
The natural product tannic acid has anti-fibrotic effects on cultured human lung fibroblasts and in an in vivo idiopathic pulmonary fibrosis (IPF) mouse model by reducing signals from TGF-beta receptors, a new study has found. The study, “…
At-home use of wearable physical activity trackers and portable spirometry devices may offer a feasible way of evaluating people with idiopathic pulmonary fibrosis (IPF) taking part in clinical trials, a small study suggests. These findings were reported in “Mobile Health Monitoring in Patients with Idiopathic Pulmonary Fibrosis,”…
Mutations in two genes, S100A3 and S100A13, were found to be linked to an atypical, early onset form of pulmonary fibrosis (PF) in two families in Saudi Arabia. The newly identified gene variants add to knowledge of the underlying mechanisms of PF development, and further support the involvement of calcium metabolism in…
When idiopathic pulmonary fibrosis (IPF) runs in families, it tends to begin earlier in life and be more severe, a recent study reported. The study,”Clinical characteristics of patients with familial idiopathic pulmonary fibrosis (f-IPF),” was published in the journal BMC Pulmonary Medicine. As its name…
