Circadian Clock of Cells in Lung Appears Troubled in Pulmonary Fibrosis, Study Finds

The molecular clockwork that regulates circadian rhythms can become dysregulated in the lungs of people with pulmonary fibrosis, promoting processes that scar lung tissue, a study suggests. Poor sleeping habits also appear to upset the lungs’ circadian clockwork, with people who regularly sleep few or excessive hours being more likely…

While preparing for my family to visit at Christmastime, I was reminded of when my mom, Holly, was discharged from the hospital after her double-lung transplant. We had to make adaptations to make our rented apartment a safe environment for her.   She had been in…

Throughout 2019, Pulmonary Fibrosis News provided you daily coverage of breakthrough discoveries, promising therapies, and clinical trials related to pulmonary fibrosis (PF). As we look forward to bringing more news to patients, family members, and caregivers dealing with PF in 2020, here are the top 10 most-read articles of 2019,…

These past six weeks have been difficult as I continue to recover from a horrible ordeal with both pneumonia and influenza. While I’ll never know how I came into contact with these viruses, I’ve become paranoid about touching surfaces such as grocery cart handles and doorknobs because of my…

I’ve held three full-time jobs in my career, each averaging about 40 hours per week. I’ve never tracked the number of hours I spend managing my chronic illness, but it wouldn’t surprise me if they equate to a full-time workweek. Since being diagnosed with idiopathic pulmonary fibrosis (IPF) three years ago,…

Overactivation of a protein called mucin 1 (MUC1) triggers pro-fibrotic transformations in the lungs that could contribute to the development and progression of idiopathic pulmonary fibrosis (IPF), an early study using patient cells and mice has found. The research furthers knowledge about the roles played by MUC1-induced pathways,…

As I move through the seasons of this year, I can’t help but feel the imprint of the events and emotions of last year. I keep comparing moments from now to this time one year ago. There are many unofficial anniversaries that my internal clocks have kept. As we…

Cohbar’s new investigational mitochondrial peptide (a small protein) called MBT#2, not only prevented scarring (fibrosis), but also slowed disease progression when fibrosis was already established in a mouse model of idiopathic pulmonary fibrosis (IPF), according to preclinical data. The new data was shared on the company’s website…

miRagen Therapeutics is reshaping its strategy to focus on the development of MRG-229, a potential treatment for idiopathic pulmonary fibrosis (IPF). The company expects to share new efficacy and safety preclinical data on MRG-229 during the…

When I was diagnosed with idiopathic pulmonary fibrosis (IPF) three years ago, I had never heard of the disease. I was told that it was rare. Even rarer, my doctors said, was my diagnosis at 28. They had considered IPF when first looking for answers for my breathlessness,…