Indalo Therapeutics announced that dosing has begun in the first patient enrolled in its Phase 1 trial assessing the safety, tolerability, and properties of IDL-2965, the company’s lead candidate to treat fibrotic diseases including idiopathic pulmonary fibrosis (IPF). IDL-2965 is an oral, selective antagonist of three types…
First IPF Patient Dosed in Phase 1 Trial of Potential Oral Anti-fibrotic Therapy, Indalo Announces
After my single-lung transplant in December 2015, I was invited to participate in a panel of idiopathic pulmonary fibrosis (IPF) and lung transplant patients who had previously taken the anti-fibrotic medications Ofev (nintedanib) or Esbriet (pirfenidone). My pulmonologist had asked me to take part in a…
For the third day in a row, I’ve been feeling angry with my body, particularly my lungs. I’ve been experiencing severe breathlessness. While I don’t have signs of a viral or bacterial infection, I’m struggling to hold a conversation because of my need to pause frequently. This level of…
Veracyte announced new data further supporting its Envisia Genomic Classifier as a useful tool in helping doctors to diagnosis idiopathic pulmonary fibrosis (IPF) with greater confidence and without the need for surgery to biopsy lung…
Healthy and idiopathic pulmonary fibrosis (IPF) lung cells respond differently to transforming growth factor-beta 1 (TGF-beta 1) — a key mediator of fibrosis — both in terms of gene activity and DNA methylation, likely due to the fibrotic environment that IPF cells are exposed to in the lungs,…
No significant differences in survival rates, extending out 10 years, were found in idiopathic pulmonary fibrosis (IPF) patients given either a single- or double-lung transplant, a study reports. These findings, based on data cover more than 2,000 IPF patients who underwent either, suggest a bias in studies favoring a…
I have spent a lot of time writing about self-care and mental health as a caregiver. Even if the term “self-care” sounds silly to you, I recommend dedicating time every day to your mental health. If for no other reason than to help prevent caregiver burnout.
A positron emission tomography (PET) tracer that recognizes a potential protein biomarker of fibrotic interstitial lung diseases can be used to detect idiopathic pulmonary fibrosis (IPF) and several cancers in PET scans, a pilot clinical study suggests. The research, “Evaluation of integrin αvβ6 cystine knot PET tracers to…
If you’re aware of “FOMO,” you’ll know that it stands for “fear of missing out.” It can be used to describe the feeling that many people have of wanting to experience everything that life has to offer. Sometimes FOMO can lead to people compromising their physical health by depriving…
Fast weight loss in people with idiopathic pulmonary fibrosis (IPF), even after lung transplant, is linked with worse prognosis, and may indicate immune system activation, a study suggests. People who experience greater weight loss over a short period may be at greater risk for poor outcomes. The research, “…
