PARP-1 Blocker Lessens Symptoms of Lung Fibrosis in Mouse Study of IPF

PARP-1 Blocker Lessens Symptoms of Lung Fibrosis in Mouse Study of IPF

Inhibiting PARP-1 protein expression eased several symptoms of lung fibrosis in a mice model of the disease. These results suggest that PARP-1 inhibitors may carry therapeutic potential for patients with idiopathic pulmonary fibrosis (IPF). The study, “HYDAMTIQ, a selective PARP-1 inhibitor, improves bleomycin-induced lung fibrosis by dampening the TGF-β/SMAD signalling…

Everyday Living With Idiopathic Pulmonary Fibrosis

In this video from the Canadian Pulmonary Fibrosis Foundation shared in September 2014, we meet some patients and family members who are living with idiopathic pulmonary fibrosis. They talk about how the disease has impacted their lives, the symptoms they are dealing with and the choices they have had to…

Natural Anticoagulant Protected Mice from Severe Lung Fibrosis

Mice that produce excessive amounts of an anticoagulant factor are somewhat protected against pulmonary fibrosis development, a finding that highlights the possibility of manipulating natural anti-clotting proteins in the fight against lung fibrosis. Experiments showed that high levels of the anticoagulant protein C caused fewer macrophage inflammatory cells to move…

Identifying IPF Patients for Esbriet Use

In this MD Magazine TV video, Dr. Benjamin Kramer from Genentech talks about the types of patients who would benefit from taking Esbriet–a medication for pulmonary fibrosis patients. Find out more about what is happening in the research of idiopathic pulmonary fibrosis.  Dr. Kramer explains that due…

Well-intended, Infuriating Comments

I read an article yesterday in Pulmonary Fibrosis News that told about a woman who was diagnosed with idiopathic pulmonary fibrosis (IPF) in June. Her disease is progressing so fast that she needs a double lung transplant now – like now. She is on the transplant list, but doctors say that…

Idiopathic Pulmonary Fibrosis Stories: Noreen

This video from the Irish Lung Fibrosis Association is all about Noreen. Noreen was diagnosed with idiopathic pulmonary fibrosis (IPF) in June 2015. Find out more about idiopathic pulmonary fibrosis in a nutshell. Noreen talks about the shock of receiving her diagnosis and worrying about how she…

Non-Invasive Diagnostic Test for IPF Shown Pulmonologists at CHEST 2016

Veracyte has announced the launch of its non-invasive test to improve the diagnosis of interstitial lung diseases, including  idiopathic pulmonary fibrosis (IPF). The soon-to-be commercially available test, Envisia Genomic Classifier, is reported to offer a faster and more accurate diagnosis than is currently available without the need for a lung biopsy. Data…