News

Mesenchymal Stromal Cells Reduced Lung Cell Aging in Mice

Mesenchymal stromal cells (MSCs) lessened lung scarring by reducing idiopathic pulmonary fibrosis (IPF)-related aging of lung cells that play a key role in tissue repair, according to a study in a mouse model of IPF. Notably, these benefits were associated with a normalization of the levels of molecules involved…

Early Trial Data Indicates NP-120 Could Ease Coughing in IPF

Patients with idiopathic pulmonary fibrosis (IPF) with chronic cough who are being treated with the investigational oral medication NP-120 (ifenprodil) in a small clinical trial tended to experience a reduction in coughing, according to the therapy’s developer Algernon Pharmaceuticals. The company is funding an open-label Phase 2…

Cudetaxestat Well-tolerated in Esbriet, Ofev Combos in Phase 1 Trial

Cudetaxestat (BLD-0409), an experimental medication for idiopathic pulmonary fibrosis (IPF) from Blade Therapeutics, was well-tolerated among healthy volunteers when given in combination with other IPF treatments — specifically nintedanib and pirfenidone — in a Phase 1 study. “These findings provide confidence in the potential to safely co-administer cudetaxestat…

Enrollment Complete for Phase 2 Trial Testing Anti-fibrotic PLN-74809

Enrollment has been completed for INTEGRIS-IPF, a Phase 2a trial testing PLN-74809, an experimental oral anti-fibrotic therapy, in people with idiopathic pulmonary fibrosis (IPF). Pliant Therapeutics, the company developing PLN-74809 and sponsoring the trial, said it is expecting top-line results to become available midway through the year. The…

Natural Fat-like Molecules Treat Established Lung Fibrosis in Mice

Lab-made versions of naturally occurring forms of nitro oleic acid effectively treated established pulmonary fibrosis (PF) in a mouse model, a study reports. These findings support the further development of these agents for reversing fibrosis, or tissue scarring, in the lungs and other organs, its scientists noted. The study,…

Fewer GI Side Effects Seen in Study of Oral LYT-100 vs Esbriet

About half of the healthy older adults given PureTech’s anti-fibrotic therapy LYT-100 (deupirfenidone) were less likely to report gastrointestinal (GI) side effects compared with those given Esbriet (pirfenidone), according to a recent crossover study. Based on these findings, data to date from LYT-100’s clinical program and regulatory feedback, the…

MannKind, Thirona Bio Extending Joint Work on Inhalable PF Therapy

MannKind Corporation has extended its collaboration with Thirona Bio to continue work toward an inhaled therapy for fibrotic diseases affecting the lungs, including idiopathic pulmonary fibrosis (IPF). Under a collaboration established last year, the companies are evaluating the therapeutic potential of FBM5712, an investigational medicine designed to…

Untreated IPF Linked to 50% Mortality Rate at 3 Years

If left untreated by anti-fibrotic medications, idiopathic pulmonary fibrosis (IPF) has a 50% mortality rate after three years, according to a recent observational study using real-world data. This is compared with a 26–31% mortality rate among IPF patients taking available anti-fibrotics, such as Esbriet (pirfenidone) and Ofev…

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