News

Synairgen Releases Data Showing Early Potential for LOXL2 Inhibitor to Treat IPF

Synairgen released further positive data from its lysyl oxidase-like 2 enzyme (LOXL2) inhibitor program to treat idiopathic pulmonary fibrosis (IPF), being conducted in collaboration with Pharmaxis. A Phase 1 clinical trial is set to start this year, if toxicology studies are successfully completed. Synairgen and Pharmaxis entered a collaboration in August…

Mayo Clinic Study Links Biology of Aging and IPF, Opens New Paths for Possible Therapies

A new Mayo Clinic study has demonstrated new evidence of the link between the biology of aging and idiopathic pulmonary fibrosis (IPF). The study, “Cellular senescence mediates fibrotic pulmonary disease,” appeared in this month’s issue of Nature Communications  and point towards new possible directions for therapies targeting IPF. “Idiopathic pulmonary fibrosis…

Trial of AEOL 10150 as Treatment for Lung Radiation Exposure Gets Under Way

Aeolus Pharmaceuticals has started a Phase 1 clinical trial to evaluate a new version of AEOL 10150 as a treatment for delayed effects of acute lung radiation exposure(Lung-ARS). The open-label, single-center Phase 1 trial will evaluate the safety, tolerability and pharmacokinetics in healthy individuals of increasing doses of AEOL…

PBI-4050 Seen to Be Safe and Effective IPF Therapy in Phase 2 Study

PBI-4050 is a safe and effective therapy for patients with idiopathic pulmonary fibrosis (IPF), according to results of the now-completed Phase 2 clinical trial developed by ProMetic Life Sciences. The open-label, single-arm, Phase 2 study (NCT02538536) enrolled 40 IPF patients at six different sites in Canada to investigate the safety,…