Naftopidil treatment causes growth arrest of human lung fibroblasts and reduces fibrotic lesions in mice with idiopathic pulmonary fibrosis (IPF), a study shows. The findings of the study, “Naftopidil reduced the proliferation of lung fibroblasts and bleomycin‐induced lung fibrosis in mice,” were published in the Journal…
Naftopidil Inhibits Proliferation of Human Lung Fibroblasts and Reduces Lung Fibrosis in Mice, Study Finds
Bridge Biotherapeutics’ investigational therapeutic candidate BBT-877 for idiopathic pulmonary fibrosis (IPF) was found to be safe and well-tolerated in the single-ascending dose phase of a Phase 1 trial with healthy volunteers, the company announced. BBT-877 is currently undergoing testing in the multi-ascending dose phase, and Bridge Biotherapeutics is planning a…
Measuring three specific biomarkers — nitric oxide, PGE2, and 8‐isoprostane — in the exhaled breath condensates (EBC) or bronchoalveolar lavage fluids (BALF) of patients with different forms of interstitial lung disease or other lung diseases does not show diagnostic potential, a study suggests. The study, “Exhalative Breath Markers Do…
Each person’s experience of having a sick parent is different. For me, it was relatively easy until my mom’s condition became a crisis. From the start, I refused to research any terms that I’d overheard. I didn’t want to know what Dr. Google had to say about “interstitial lung…
Being diagnosed with any type of life-threatening illness will inevitably change a person. This is especially true when there is no link (i.e., genetic predisposition) or reason to think that anything could be wrong, or when the illness is unlikely to target someone due to their age. That was my…
With 250 rare diseases newly identified every year, scientists can barely keep up — even as the healthcare system fails millions of Americans whose rare diseases have already been diagnosed. That’s the warning from Christopher P. Austin, MD, director of the National Center for Advancing Translational Studies(NCATS) at the…
Loss of productivity in the workplace is common among patients with fibrotic interstitial lung disease (ILD), and is associated with symptom severity and higher costs, according to data from a Canadian registry study. The study, “Costs of Workplace Productivity Loss in Patients with Fibrotic Interstitial Lung Disease,” was…
High levels of nitric oxide in the lungs of people with idiopathic pulmonary fibrosis (IPF) are associated with faster disease progression and worse survival, researchers in Italy report. The findings were described in the study “Alveolar concentration of nitric oxide as a prognostic biomarker in idiopathic…
Lung injuries caused during the progression of pulmonary fibrosis can lead to an increase in two inflammatory proteins, IL-6 and IL-33, which can trigger muscle damage and weight loss, a mouse study says. The study, “Elevation of IL-6 and IL-33 Levels in Serum Associated with Lung…
It is hard to admit that my chronic lung disease is having more than a physical impact on me. Idiopathic pulmonary fibrosis (IPF) is a relentless, cruel disease and sometimes it causes me to behave in ways that leave me feeling ashamed. This disease sets me apart from most of…
