An extract from an earthworm reduced inflammation and fibrosis in the lungs of mice exposed to silica, acting through known antioxidant and anti-inflammatory molecular pathways. The findings suggest the extract could be explored as a potential drug therapy for silicosis. The study, “Earthworm extract attenuates silica-induced pulmonary…
Inhibiting PARP-1 protein expression eased several symptoms of lung fibrosis in a mice model of the disease. These results suggest that PARP-1 inhibitors may carry therapeutic potential for patients with idiopathic pulmonary fibrosis (IPF). The study, “HYDAMTIQ, a selective PARP-1 inhibitor, improves bleomycin-induced lung fibrosis by dampening the TGF-β/SMAD signalling…
The necessity of clinical trials for pulmonary fibrosis in an era where there are effective therapies and the challenges the trials face in order to be successful are both discussed in this Pulmonary Fibrosis Foundation video. Dr. Luca Richeldi, MD, PhD. suggested that there are three issues that need…
It’s no surprise that sometimes people say things they don’t want to–or mean to. Especially when they’re talking to someone with a disease like pulmonary fibrosis (PF), that is not fully understood by those who don’t live with it. To help you learn more about what you shouldn’t say to…
In this video from the Canadian Pulmonary Fibrosis Foundation shared in September 2014, we meet some patients and family members who are living with idiopathic pulmonary fibrosis. They talk about how the disease has impacted their lives, the symptoms they are dealing with and the choices they have had to…
Mice that produce excessive amounts of an anticoagulant factor are somewhat protected against pulmonary fibrosis development, a finding that highlights the possibility of manipulating natural anti-clotting proteins in the fight against lung fibrosis. Experiments showed that high levels of the anticoagulant protein C caused fewer macrophage inflammatory cells to move…
In this MD Magazine TV video, Dr. Benjamin Kramer from Genentech talks about the types of patients who would benefit from taking Esbriet–a medication for pulmonary fibrosis patients. Find out more about what is happening in the research of idiopathic pulmonary fibrosis. Dr. Kramer explains that due…
Treating yourself with kindness and compassion is essential for a healthy and balanced life, especially for those with pulmonary fibrosis As a marriage and family therapist for the past 30 years, I have walked in the trenches with people going through very difficult times. I…
I read an article yesterday in Pulmonary Fibrosis News that told about a woman who was diagnosed with idiopathic pulmonary fibrosis (IPF) in June. Her disease is progressing so fast that she needs a double lung transplant now – like now. She is on the transplant list, but doctors say that…
This video from the Irish Lung Fibrosis Association is all about Noreen. Noreen was diagnosed with idiopathic pulmonary fibrosis (IPF) in June 2015. Find out more about idiopathic pulmonary fibrosis in a nutshell. Noreen talks about the shock of receiving her diagnosis and worrying about how she…
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