Note: This story was updated June 11, 2021, to clarify the Chan Zuckerberg Initiative supported the Human Cell Atlas Project, in addition to other scientific initiatives. Researchers have created a comprehensive blueprint of healthy lung vascular cells, whose dysfunction is associated with pulmonary fibrosis (PF) and other lung…
New Atlas of Lung Vascular Cells May Advance PF Care, Treatment
When I write about my lung transplant, I honor my donor, for whom I am forever grateful. I didn’t know him, but I know he was a caring person. Last August, I was the lucky recipient of his lungs, which changed my life like nothing else has, or ever…
One of the most important blessings in life is having a strong support group. A support team may consist of family members, friends, or a community of people. My support team included three of the greatest people in my life: my husband, daughter, and mother. It is important…
Scientists have found a small molecule, called ISRIB, that was able to reduce fibrosis (scarring) and other disease-related features in mice with induced pulmonary fibrosis (PF). ISRIB successfully enhanced the repair process in lung cells that is altered in PF, especially…
Progressive lung diseases like pulmonary fibrosis cause ripple effects throughout the body. In PF, lung scarring prevents the organs from exchanging gases correctly, resulting in oxygen deficits known as hypoxemia and hypoxia. Chronic hypoxemia, or low oxygen levels in the blood, affects all parts of the body.
An experimental therapy that proved ineffective in treating HIV infections now has shown promising potential at preventing or limiting pulmonary fibrosis (PF) caused by SARS-CoV-2, the virus that causes COVID-19. That finding, from a mouse model of induced PF, was detailed in the study “Targeting RUNX1…
While you can’t predict an emergency, it helps to be prepared for one. Most young adults haven’t had to think about whom to notify during a medical emergency, but I have as a result of my idiopathic pulmonary fibrosis. Two years ago, I published a column about the importance for…
My mom, Diana, relied on a plug-in oxygen machine to breathe, and the power was going to be shut off for days. This was back in the late summer of 2019, when she was still on the lung…
DWN12088, an investigational therapy for idiopathic pulmonary fibrosis (IPF), showed promising anti-fibrotic properties and appeared to be safe and well-tolerated in a recently-completed Phase 1 clinical trial that enrolled healthy volunteers. Daewoong Pharmaceutical, the therapy’s developer, now plans to start a Phase 2 trial later this year. “We…
High-dose AP01 (inhaled pirfenidone) largely prevented lung function decline and was safe and well-tolerated during the first 24 weeks of a Phase 1/2 clinical study testing its use in patients with idiopathic pulmonary fibrosis (IPF). Avalyn Pharma, the therapy’s developer, presented the results at the 2021…
