Inhibiting Inflammation-promoting Enzyme Slows Lung Tissue Scarring, Mouse Study Shows

Inhibiting Inflammation-promoting Enzyme Slows Lung Tissue Scarring, Mouse Study Shows

Inhibiting an inflammation-promoting enzyme known as sialidase slowed lung tissue scarring in mice with pulmonary fibrosis, a study shows. The research indicated that sialidase inhibitors, such as Tamiflu, could be used to treat idiopathic pulmonary fibrosis, or IPF. The underlying causes of fibrosis in diseases such as IPF and asthma are still…

I’ve Lost a Lot But I’m Still Thankful

As the seasons slowly change here in Southwestern Ontario and we welcome the beauty of fall, I can’t help but reflect on this past summer. It was filled with some happy memories, but also hard times as my disease progressed and my lungs struggled with the heat and…

When to Consider Professional Help While Dealing With PF

It would likely come as no surprise to others that patients diagnosed with a life-threatening illness, such as pulmonary fibrosis (PF), have many intense emotions and valid fears associated with their disease. These emotions can manifest themselves in many different ways. For example, even the emotions associated with a positive…

U.S. and Canadian Study Identifies Signaling Pathway That Promotes Lung Scarring

U.S. and Canadian researchers have identified a signaling pathway that promotes lung and skin scarring. Although the study involved mice, the team said the pathway is likely involved in the progression of idiopathic pulmonary fibrosis (IPF) in humans as well. Targeting the pathway may be a way to treat IPF and other fibrotic…

Real-world Clinical Data Back Envisia Genomic Classifier’s Potential for IPF Diagnoses

The diagnostic potential of the Envisia Genomic Classifier to distinguish idiopathic pulmonary fibrosis (IPF) from other interstitial lung diseases (ILDs) has once again been demonstrated, this time with data collected in real-world clinical settings. The test, developed by Veracyte, helped improve the accuracy and effectiveness of IPF diagnoses by…

Seeking Palliative Care

I recently met with someone to talk about palliative care. I’m here to share my experience in hopes it will help you, too. My last column about end-stage PF had thousands of views and LOTS of comments, which shows how important it is to talk about these…

Pain and IPF: What’s the Deal?

I am sure there is some underlying rule that a patient will have some type of pain when diagnosed with a chronic illness. Either that pain will come from the disease itself, or it will be a secondary symptom of it, such as inflammation, sore muscles, etc. Until…

OFEV Slows Progression of Fibrosis, Lung Imaging in Phase 3b Trial Shows

Pulmonary fibrosis treatment OFEV (nintedanib) slows the progression of lung scarring, according to high-resolution scans used in a Phase 3b clinical trial. Computed tomography imaging demonstrated for the first time that six months of Ofev could reduce  the progression of patients’ lung fibrosis lesions, compared with a placebo. Two…

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