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    • #16394
      Brian Sowter
      Participant

      I take Ofev and I have atrial fibrilation which is well controlled by a drug called Flecainide.  My GP wants me to take an anticoagulant Warfarin but my lung consultant tells me that Ofev tends to thin the blood and is not compatible with any anticoagulatio therapy because of the increased risk of bleeding.

      Has anybody had experience of this?

    • #16429

      Hi Brian,

      Thanks so much for getting in touch and starting this important topic thread! It isn’t something I’ve ever experienced, but I’d be curious to know if others have and read their thoughts. I know lots of people post-transplant struggle through a-fib issues so I’d think they would need different drugs to regulate their heart-rhythm and wonder if they would know if it caused an increased risk of bleeding? However, I guess post-transplant they aren’t dealing with Ofev any longer though…. hm, good question! I would be more inclined to go with the lung specialists thoughts personally, but of course that is dependent on your comfort with both doctors. Any chance you could call the manufacturers of Ofev and ask their thoughts? Please keep us posted if you can.

      Thanks,
      Charlene.

    • #16447
      John K. Mortimer
      Participant

      Hi Brian,

      I have IPF but do not take OFEV.  I do take warfarin.  I would tend to take the advice of your lung doctor, but would also recommend you contact the anticoagulation unit at your hospital.  The pharmacists there give advice daily to folks taking warfarin, and can give you in depth information on drug interactions.  In my case they have recommended warfarin dosage adjustments to keep my blood appropriately “thin”, while I was taking other meds temporarily to address other issues.

      Best of luck,

      John Mortimer

      • #16453

        Thanks for this reply John, I appreciated reading your contributions! I am interested in this topic for sure, and good suggestion about circling back to the anticoagulation unit at the hospital for information about any drug interactions with Warfarin. Hope you’re doing well!

        Charlene.

    • #16569
      Brian Sowter
      Participant

      Thanks John and Charlene

      I say my pulmonary consultant yesterday and ended up with a prescription for Rivaroxaban which is one of the modern anticoagulants.  There is an increased risk of bleeding when taken with Ofev but I decided to go for it as I think this is a better risk than getting a stroke because of A-Fib.  There is really no significant data on which to base the decision but I certainly do not want to stop Ofev.

      I was told that there are a small number of Ofev patients in the UK who do take this combination in spite of the increased risk of bleeding.  Ofev apparently affects the platelets which are part of the clotting process hence the bleeding risk. Its effect cannot be measured with the INR test used with Warfarin.   One benefit of Rivaroxaban  is that the half life is only a  few hours compared with a few days with Warfarin. It’s better this way if you do get a bleed or need some emergency surgery.  If I do get a bleed I need to stop both drugs.

       

       

       

    • #16583

      Hi Brian,

      Thanks for reporting back to us and letting us know how it went with the Pulmonologist. I think I’d lean towards your decision too, as I wouldn’t want to stop the OFEV , especially if you’re finding it helpful/effective. I hope it goes well for you, and you don’t run into any issues with the new script you’ve received. I’ll keep my fingers crossed that you don’t experience any bleeding or other drug-related difficulties. Thanks for sharing!

      Charlene.

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